CTR3_YEAST
ID CTR3_YEAST Reviewed; 241 AA.
AC Q06686; D6VZ47;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Copper transport protein CTR3;
DE Short=Copper transporter 3;
GN Name=CTR3; OrderedLocusNames=YLR411W; ORFNames=L9931.6;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=ATCC 96099 / S288c / SEY6210;
RX PubMed=8756349; DOI=10.1101/gad.10.15.1917;
RA Knight S.A.B., Labbe S., Kwon L.F., Kosman D.J., Thiele D.J.;
RT "A widespread transposable element masks expression of a yeast copper
RT transport gene.";
RL Genes Dev. 10:1917-1929(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Required for high affinity copper (probably reduced Cu I)
CC transport into the cell.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane
CC protein.
CC -!- INDUCTION: By copper deprivation and repressed by copper excess.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; U81482; AAB40707.1; -; Genomic_DNA.
DR EMBL; U20162; AAB67496.1; -; Genomic_DNA.
DR EMBL; AY692929; AAT92948.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09713.1; -; Genomic_DNA.
DR PIR; S59377; S59377.
DR RefSeq; NP_013515.3; NM_001182299.3.
DR AlphaFoldDB; Q06686; -.
DR SMR; Q06686; -.
DR BioGRID; 31670; 22.
DR DIP; DIP-4285N; -.
DR IntAct; Q06686; 2.
DR MINT; Q06686; -.
DR STRING; 4932.YLR411W; -.
DR TCDB; 1.A.56.1.4; the copper transporter (ctr) family.
DR PaxDb; Q06686; -.
DR PRIDE; Q06686; -.
DR EnsemblFungi; YLR411W_mRNA; YLR411W; YLR411W.
DR GeneID; 851129; -.
DR KEGG; sce:YLR411W; -.
DR SGD; S000004403; CTR3.
DR VEuPathDB; FungiDB:YLR411W; -.
DR eggNOG; KOG3386; Eukaryota.
DR HOGENOM; CLU_079690_0_0_1; -.
DR InParanoid; Q06686; -.
DR OMA; NACKISM; -.
DR BioCyc; YEAST:G3O-32473-MON; -.
DR PRO; PR:Q06686; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06686; protein.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IDA:SGD.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR GO; GO:0015677; P:copper ion import; IDA:SGD.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 1: Evidence at protein level;
KW Copper; Copper transport; Cytoplasmic vesicle; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..241
FT /note="Copper transport protein CTR3"
FT /id="PRO_0000195047"
FT TOPO_DOM 1..41
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..182
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 241 AA; 27534 MW; 9BFDFB9DE1EDD75C CRC64;
MNMGGSSSTA AKKATCKISM LWNWYTIDTC FIARSWRNDT KGKFAGSCIG CFALVVVAQW
LTRFSRQFDV ELLKRQKIKH LASYSPEEYV VKCGEEDAKS DIEELQGFYN EPSWKTTLIS
LQKSFIYSFY VWGPRRLNEP EDDLLKKVLS CCTLITPVDL YPTFLDHMIR VTIFVLQWGL
SYIIMLLFMY YNGYIIISCL IGAIVGRFIF CYEPLGSLGA NGSAQGTVSY DKESDDRKCC
L
