CTR4_MOUSE
ID CTR4_MOUSE Reviewed; 635 AA.
AC Q8BLQ7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Cationic amino acid transporter 4;
DE Short=CAT-4;
DE Short=CAT4;
DE AltName: Full=Solute carrier family 7 member 4;
GN Name=Slc7a4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422 AND SER-427, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the transport of the cationic amino acids
CC (arginine, lysine and ornithine). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000305}.
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DR EMBL; AK043772; BAC31651.1; -; mRNA.
DR EMBL; AK162398; BAE36893.1; -; mRNA.
DR CCDS; CCDS28008.1; -.
DR RefSeq; NP_659101.2; NM_144852.3.
DR RefSeq; XP_017172438.1; XM_017316949.1.
DR RefSeq; XP_017172439.1; XM_017316950.1.
DR RefSeq; XP_017172440.1; XM_017316951.1.
DR AlphaFoldDB; Q8BLQ7; -.
DR SMR; Q8BLQ7; -.
DR STRING; 10090.ENSMUSP00000127280; -.
DR GlyGen; Q8BLQ7; 4 sites.
DR iPTMnet; Q8BLQ7; -.
DR PhosphoSitePlus; Q8BLQ7; -.
DR SwissPalm; Q8BLQ7; -.
DR PaxDb; Q8BLQ7; -.
DR PRIDE; Q8BLQ7; -.
DR ProteomicsDB; 285351; -.
DR Antibodypedia; 23447; 98 antibodies from 25 providers.
DR DNASU; 224022; -.
DR Ensembl; ENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
DR Ensembl; ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
DR GeneID; 224022; -.
DR KEGG; mmu:224022; -.
DR UCSC; uc007ylk.1; mouse.
DR CTD; 6545; -.
DR MGI; MGI:2146512; Slc7a4.
DR VEuPathDB; HostDB:ENSMUSG00000022756; -.
DR eggNOG; KOG1286; Eukaryota.
DR GeneTree; ENSGT00940000154637; -.
DR HOGENOM; CLU_007946_15_7_1; -.
DR InParanoid; Q8BLQ7; -.
DR OMA; VGTWQVP; -.
DR OrthoDB; 600052at2759; -.
DR PhylomeDB; Q8BLQ7; -.
DR TreeFam; TF315212; -.
DR BioGRID-ORCS; 224022; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BLQ7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8BLQ7; protein.
DR Bgee; ENSMUSG00000022756; Expressed in prostate gland ventral lobe and 161 other tissues.
DR ExpressionAtlas; Q8BLQ7; baseline and differential.
DR Genevisible; Q8BLQ7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..635
FT /note="Cationic amino acid transporter 4"
FT /id="PRO_0000304934"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 422
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 427
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 635 AA; 68350 MW; B4A13B84EFED7587 CRC64;
MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM VGSGLYVLTG
TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG SAYLFTYVSM GEIWAFLIGW
NVLLEYLIGG AAVARAWSGY LDAIFNHSIR NFTESHLGVW QVPFLAHYPD FLAAGILLVA
SAFVSCGARV SSWLNHTFSA ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG
TATCFYAFVG FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD
PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD GLFFQVFARV
HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL AYTFVATSII VLRFQKASPP
SSPCLASPGP TAKKYDSFSD HIQLVGAEQT SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW
ALGILVASAI SLACVLVFGN SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF
QIPLVPLTPA LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL
TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE
