CTR5_SCHPO
ID CTR5_SCHPO Reviewed; 173 AA.
AC Q9P7F9;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Copper transport protein ctr5;
DE Short=Copper transporter 5;
GN Name=ctr5; ORFNames=SPAC1142.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, INTERACTION WITH CTR4, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=11274192; DOI=10.1074/jbc.m102004200;
RA Zhou H., Thiele D.J.;
RT "Identification of a novel high affinity copper transport complex in the
RT fission yeast Schizosaccharomyces pombe.";
RL J. Biol. Chem. 276:20529-20535(2001).
CC -!- FUNCTION: Required for high affinity copper (probably reduced Cu I)
CC transport into the cell. {ECO:0000269|PubMed:11274192}.
CC -!- SUBUNIT: Interacts with ctr4. {ECO:0000269|PubMed:11274192}.
CC -!- INTERACTION:
CC Q9P7F9; O94722: ctr4; NbExp=2; IntAct=EBI-1561942, EBI-1561952;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11274192}; Multi-
CC pass membrane protein {ECO:0000269|PubMed:11274192}.
CC -!- INDUCTION: By copper deprivation, and repressed by copper sufficiency.
CC {ECO:0000269|PubMed:11274192}.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; CU329670; CAB77012.1; -; Genomic_DNA.
DR RefSeq; NP_594269.1; NM_001019692.2.
DR AlphaFoldDB; Q9P7F9; -.
DR SMR; Q9P7F9; -.
DR BioGRID; 279389; 4.
DR IntAct; Q9P7F9; 1.
DR STRING; 4896.SPAC1142.05.1; -.
DR TCDB; 1.A.56.1.5; the copper transporter (ctr) family.
DR MaxQB; Q9P7F9; -.
DR PaxDb; Q9P7F9; -.
DR EnsemblFungi; SPAC1142.05.1; SPAC1142.05.1:pep; SPAC1142.05.
DR GeneID; 2542949; -.
DR KEGG; spo:SPAC1142.05; -.
DR PomBase; SPAC1142.05; ctr5.
DR VEuPathDB; FungiDB:SPAC1142.05; -.
DR eggNOG; KOG3386; Eukaryota.
DR HOGENOM; CLU_079690_0_2_1; -.
DR InParanoid; Q9P7F9; -.
DR OMA; DETTVCC; -.
DR PhylomeDB; Q9P7F9; -.
DR PRO; PR:Q9P7F9; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0000324; C:fungal-type vacuole; IDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR GO; GO:0098705; P:copper ion import across plasma membrane; IMP:PomBase.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 1: Evidence at protein level;
KW Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..173
FT /note="Copper transport protein ctr5"
FT /id="PRO_0000195049"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 173 AA; 19012 MW; 435BF087296B4E55 CRC64;
MSLSKMSMSG MSGMGMGSSS NSSAATCRMS MLWNWYIHDS CFLAKSWHIN TGNKFAGSII
GIFFFAVAIE GLSLVQRMFD RWIVAHSNGK TLSGPLRIFF PSSTVHVTVW QQLIRAAMYS
SFYLSATILM LIVMSFNGYA ILFGFVGAWI GFFLFASDTY GTPSTGTGCC ESR
