CTR6_SCHPO
ID CTR6_SCHPO Reviewed; 148 AA.
AC Q9USV7;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Copper transport protein ctr6;
DE Short=Copper transporter 6;
GN Name=ctr6; ORFNames=SPBC23G7.16;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=12244050; DOI=10.1074/jbc.m206444200;
RA Bellemare D.R., Shaner L., Morano K.A., Beaudoin J., Langlois R., Labbe S.;
RT "Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces
RT pombe.";
RL J. Biol. Chem. 277:46676-46686(2002).
CC -!- FUNCTION: Mobilizes stored copper from the vacuole to the cytoplasm
CC under conditions of copper limitation. {ECO:0000269|PubMed:12244050}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000269|PubMed:12244050}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:12244050};
CC Multi-pass membrane protein {ECO:0000269|PubMed:12244050}.
CC -!- INDUCTION: By copper deprivation. {ECO:0000269|PubMed:12244050}.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; CU329671; CAB58134.1; -; Genomic_DNA.
DR PIR; T39949; T39949.
DR RefSeq; NP_595861.1; NM_001021766.2.
DR AlphaFoldDB; Q9USV7; -.
DR SMR; Q9USV7; -.
DR BioGRID; 277166; 5.
DR STRING; 4896.SPBC23G7.16.1; -.
DR TCDB; 1.A.56.1.6; the copper transporter (ctr) family.
DR MaxQB; Q9USV7; -.
DR PaxDb; Q9USV7; -.
DR PRIDE; Q9USV7; -.
DR EnsemblFungi; SPBC23G7.16.1; SPBC23G7.16.1:pep; SPBC23G7.16.
DR GeneID; 2540641; -.
DR KEGG; spo:SPBC23G7.16; -.
DR PomBase; SPBC23G7.16; ctr6.
DR VEuPathDB; FungiDB:SPBC23G7.16; -.
DR eggNOG; KOG3386; Eukaryota.
DR HOGENOM; CLU_079690_4_0_1; -.
DR InParanoid; Q9USV7; -.
DR OMA; MNMIFTW; -.
DR PhylomeDB; Q9USV7; -.
DR Reactome; R-SPO-425410; Metal ion SLC transporters.
DR PRO; PR:Q9USV7; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR GO; GO:0140145; P:copper ion export from vacuole; EXP:PomBase.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 1: Evidence at protein level;
KW Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..148
FT /note="Copper transport protein ctr6"
FT /id="PRO_0000195050"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..148
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 148 AA; 16747 MW; D5E214905DBB0491 CRC64;
MNHGGNSTMR HCSMKMTFNT DYDNLCIVFK SWHIGNLSQF LLSLLAIAIL GYLFERLRSF
TSLKETEFQR GYAGQQSEGL LTHHSKSLKS GRPFRLCALY AVQLVFSYFL MLVAMTYNAY
VILAIAIGAA FGYRRSHCDT VQTVGLCH
