CTR86_YEAST
ID CTR86_YEAST Reviewed; 563 AA.
AC P25355; D6VR62;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Copper transport protein 86;
GN Name=CTR86; OrderedLocusNames=YCR054C; ORFNames=YCR54C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2204248; DOI=10.1002/yea.320060408;
RA Mannhaupt G., van der Linden C.G., Vetter I., Maurer K., Pilz U.,
RA Planta R.J., Feldmann H.;
RT "Analysis of the THR4 region on chromosome III of the yeast Saccharomyces
RT cerevisiae.";
RL Yeast 6:353-361(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-433 AND SER-559, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Essential protein which may be involved in threonine
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the CTR86 family. {ECO:0000305}.
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DR EMBL; X59720; CAA42285.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07531.1; -; Genomic_DNA.
DR PIR; S22837; S22837.
DR RefSeq; NP_009983.1; NM_001178768.1.
DR AlphaFoldDB; P25355; -.
DR BioGRID; 31034; 83.
DR DIP; DIP-2728N; -.
DR IntAct; P25355; 8.
DR MINT; P25355; -.
DR STRING; 4932.YCR054C; -.
DR iPTMnet; P25355; -.
DR MaxQB; P25355; -.
DR PaxDb; P25355; -.
DR PRIDE; P25355; -.
DR EnsemblFungi; YCR054C_mRNA; YCR054C; YCR054C.
DR GeneID; 850421; -.
DR KEGG; sce:YCR054C; -.
DR SGD; S000000650; CTR86.
DR VEuPathDB; FungiDB:YCR054C; -.
DR eggNOG; KOG2676; Eukaryota.
DR GeneTree; ENSGT00390000010377; -.
DR HOGENOM; CLU_043683_0_0_1; -.
DR InParanoid; P25355; -.
DR OMA; TNFPECK; -.
DR BioCyc; YEAST:G3O-29362-MON; -.
DR PRO; PR:P25355; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25355; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019156; Ataxin-10_domain.
DR Pfam; PF09759; Atx10homo_assoc; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Amino-acid biosynthesis; Cytoplasm; Phosphoprotein; Reference proteome;
KW Threonine biosynthesis.
FT CHAIN 1..563
FT /note="Copper transport protein 86"
FT /id="PRO_0000202572"
FT REGION 544..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 433
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT MOD_RES 559
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956,
FT ECO:0007744|PubMed:19779198"
SQ SEQUENCE 563 AA; 65206 MW; 38DE4EBFA781D629 CRC64;
MPMNNFLDEF NLFDSIITMM KNDPCCVEDY EPIVENLNRI FQRTFNDEEH RKSMANSQLF
WERLRDTLEA MLLPASLNEN SSIPYTRTVR GLILMMRNLA AENQEIPQKL LLQNLVIRGF
LHATSEYVVD TPLIKHLYIA CLTCLFNIQQ NYSTVDMTTF PALLQFLQYP YGIKLEDGEE
EEHFWLPYLF LFKTYLNNDE FSNEFFRDND TPQKDYYCVR DRIFFDIVTA KFIQDQENSF
LIEKGRNYLD DSKLEITSID LSVLECISKS LTTASFGKYL NGLEERQPGK FTTLLQILQL
VVTSKEDWNT YELTAIMSWC YPILQRLACK DIPAFFNKSC NDYAPSVAIQ LHSTLLSCLD
IISDLCKFNH VRKFLISYDS VKILVSLLDT FQKNLLRINF LKGNGDTVNE IKITDHEGNK
IEDRLLIFNR VNTNESFIRA DNFPHCKLVI IEILASLVYA HPEIQDQIRE LGGLALILSN
CVIDDNDPFI KERSIVCLKF LLKNNAKNQE YVKKMEAQDV VQDDALSKAG FEISVEKGGK
VRLVSKEEDP GNENSEIISI DED
