CTR9_XENTR
ID CTR9_XENTR Reviewed; 1172 AA.
AC Q6DEU9;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=RNA polymerase-associated protein CTR9 homolog;
DE AltName: Full=SH2 domain-binding protein 1;
GN Name=ctr9; Synonyms=sh2bp1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple
CC functions during transcription by RNA polymerase II (By similarity).
CC PAF1C associates with RNA polymerase II, is involved in transcriptional
CC elongation and in histone modifications including methylation on
CC histone H3 'Lys-4' (H3K4me3) (By similarity).
CC {ECO:0000250|UniProtKB:Q6PD62}.
CC -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex
CC interacts with PHF5A (By similarity). {ECO:0000250|UniProtKB:Q62018,
CC ECO:0000250|UniProtKB:Q6PD62}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q62018}.
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DR EMBL; BC076995; AAH76995.1; -; mRNA.
DR RefSeq; NP_001005076.1; NM_001005076.1.
DR AlphaFoldDB; Q6DEU9; -.
DR SMR; Q6DEU9; -.
DR STRING; 8364.ENSXETP00000029922; -.
DR PRIDE; Q6DEU9; -.
DR DNASU; 448648; -.
DR GeneID; 448648; -.
DR KEGG; xtr:448648; -.
DR CTD; 9646; -.
DR Xenbase; XB-GENE-5946075; ctr9.
DR eggNOG; KOG2002; Eukaryota.
DR InParanoid; Q6DEU9; -.
DR OrthoDB; 396755at2759; -.
DR Reactome; R-XTR-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-XTR-75955; RNA Polymerase II Transcription Elongation.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.
DR GO; GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.
DR GO; GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.
DR GO; GO:0051569; P:regulation of histone H3-K4 methylation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0019827; P:stem cell population maintenance; ISS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR031101; Ctr9.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14027; PTHR14027; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 11.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 10.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; TPR repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..1172
FT /note="RNA polymerase-associated protein CTR9 homolog"
FT /id="PRO_0000231591"
FT REPEAT 41..75
FT /note="TPR 1"
FT REPEAT 129..162
FT /note="TPR 2"
FT REPEAT 163..196
FT /note="TPR 3"
FT REPEAT 198..231
FT /note="TPR 4"
FT REPEAT 235..268
FT /note="TPR 5"
FT REPEAT 306..339
FT /note="TPR 6"
FT REPEAT 341..374
FT /note="TPR 7"
FT REPEAT 412..444
FT /note="TPR 8"
FT REPEAT 451..484
FT /note="TPR 9"
FT REPEAT 497..530
FT /note="TPR 10"
FT REPEAT 531..564
FT /note="TPR 11"
FT REPEAT 566..598
FT /note="TPR 12"
FT REPEAT 613..646
FT /note="TPR 13"
FT REPEAT 648..680
FT /note="TPR 14"
FT REPEAT 681..714
FT /note="TPR 15"
FT REPEAT 717..750
FT /note="TPR 16"
FT REGION 889..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 132661 MW; D06657138B0E22E9 CRC64;
MSRGSIEIPL RDTDEVIELD FDQLPEGDEV ISILKQEHTQ LHIWIALGLE YYKQVKTEDF
VKLLEAARID GNLDYRDHEK DQMTCLDTLA AYYVQQARKE KNKDNKKELI TQATLLYTMA
DKIIMYDQNH LLGRACFCLL EGDKMDQADA QFHFVLNQSP NNIPALLGKA CISFNKKDYR
GALAYYKKAL RTNPGCPAGV RLGMGHCFVK LNKLDKARLA FGRALDLNPT CVGALVGLAV
LELNNKEADS IKNGVQLLSK AYTIDPSNPM VLNHLANHFF FKKDYSKVQH LALHAFHNTE
VEAMQAESCY QLARSFHVQE DYDQAFQYYY QATQFAAASF VLPFFGLGQM YIYRGDKENA
SQCFEKVLKA YPNNYETMKI LGSLYAASDD QEKRDIAKSH LKKVTEQYPD DVEAWIELAQ
ILEQTDIQNA LSAYGTATRI LQEKVQADVP PEILNNVGAL HFRLGNLGEA KKYFLASLDR
AKAEAEHDEH YYNAISVTTT YNLARLYEGL CEFHESEKLY KNILREHPNY VDCYLRLGAM
ARDKGNFYEA SDWFKEALQI NQDHPDAWSL IGNLHLAKQE WGPGQKKFER ILKQPSTQND
TYSMLALGNV WLQTLHQPTR DREKEKRHQD RALAIYKQVL RNDSKNLYAA NGIGAVLAHK
GYVREARDVF AQVREATADI SDVWLNLAHI YVEQKQYISA VQMYENCLRK FYKHQNTEVL
LYLARALFKC GKLQECKQIL LKARHVAPND TVLMFNVALV LQRLATLVLK DEKSNLKAVL
NAVKELELAH RYFNYLSKVG DKMRFDLALA ASEARQCSDL LSQAQYHVAR ARKQDEEEKE
LRAKQEQEKE ILRQKLIKEQ EEKRLKEIEE QKKLLEQRAQ YVEKTRNLLN FTGEMETPKE
KKQRGGGGGG GGRRSKKNGE FDEFVNDDSD EDLAPRKKKR KKGGGSSGSG GEQGEGGEEG
EGGEKKKKKR RKRPQKGGDG SDDDEDQAPQ PKKRQPKKRE KPAKFERTPP SMKGKIKSKA
IISSSEDDSD EDKLKIADEG HGRGSNSDSD EGPRTQAKKR IMSDSDSDNA NKSGSGAGSP
QKSPQSDGDS DNNAWARKRR RQDSGSDNDS AQSRRSSGGS DNESRAASRS PESQRGSDRG
SDNEGSARAS PNESEQEASN NEKSDRGSDD SD
