ID   CTRA_BRUA1              Reviewed;         232 AA.
AC   B2S753;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Cell cycle response regulator CtrA;
DE   AltName: Full=Cell cycle transcriptional regulator A;
GN   Name=ctrA; OrderedLocusNames=BAbS19_I15100;
OS   Brucella abortus (strain S19).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=430066;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S19;
RX   PubMed=18478107; DOI=10.1371/journal.pone.0002193;
RA   Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S.,
RA   Bricker B., Yu G., Du L., Sobral B.W.;
RT   "Genome sequence of Brucella abortus vaccine strain S19 compared to
RT   virulent strains yields candidate virulence genes.";
RL   PLoS ONE 3:E2193-E2193(2008).
CC   -!- FUNCTION: Component of a regulatory phosphorelay system that controls
CC       B.abortus cell growth, division, and intracellular survival inside
CC       mammalian host cells. This signaling pathway is composed of CckA, ChpT,
CC       CtrA and CpdR. CtrA is a response regulator substrate of ChpT. When
CC       phosphorylated, directly regulates the expression of ccrM. Is also
CC       probably involved in the transcriptional regulation of rpoD, pleC, minC
CC       and ftsE genes. {ECO:0000250|UniProtKB:Q2YQA4,
CC       ECO:0000250|UniProtKB:Q9ZHS1}.
CC   -!- SUBUNIT: Forms an asymmetric heterotetramer with ChpT (2:2). There are
CC       at least two modes of interaction between ChpT and CtrA, only one of
CC       which is competent to catalyze His-Asp phosphoryl transfer.
CC       {ECO:0000250|UniProtKB:Q2YQA4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2YQA4}.
CC   -!- PTM: Is phosphorylated by ChpT-P on Asp-51.
CC       {ECO:0000250|UniProtKB:Q2YQA4, ECO:0000250|UniProtKB:Q9ZHS1}.
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DR   EMBL; CP000887; ACD73000.1; -; Genomic_DNA.
DR   RefSeq; WP_002964699.1; NC_010742.1.
DR   AlphaFoldDB; B2S753; -.
DR   SMR; B2S753; -.
DR   EnsemblBacteria; ACD73000; ACD73000; BAbS19_I15100.
DR   GeneID; 45124914; -.
DR   GeneID; 55591229; -.
DR   KEGG; bmc:BAbS19_I15100; -.
DR   HOGENOM; CLU_000445_30_1_5; -.
DR   OMA; QLWGYPP; -.
DR   Proteomes; UP000002565; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..232
FT                   /note="Cell cycle response regulator CtrA"
FT                   /id="PRO_0000363195"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..223
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ZHS1,
FT                   ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   232 AA;  26066 MW;  9177C2281EC76ACE CRC64;
     MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL DLNLPDMSGY
     EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT KPFHKDELIA RIHAIVRRSK
     GHAQSVITTG DLVVNLDAKT VEVAGQRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
     GMDEPELKII DVFICKLRKK LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA