ID   CTRA_CAUVC              Reviewed;         231 AA.
AC   P0CAW8; Q45994;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Cell cycle transcriptional regulator CtrA;
DE   AltName: Full=Response regulator SokA;
GN   Name=ctrA; Synonyms=sokA; OrderedLocusNames=CC_3035;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-231.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=9465034; DOI=10.1073/pnas.95.4.1443;
RA   Wu J., Ohta N., Newton A.;
RT   "An essential, multicomponent signal transduction pathway required for cell
RT   cycle regulation in Caulobacter.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:1443-1448(1998).
CC   -!- FUNCTION: Forms part of a two-component regulatory system CtrA/CckA
CC       that controls multiple events in the cell cycle, including cell
CC       division, stalk synthesis and cell cycle-specific transcription. Binds
CC       to a group of cell cycle-regulated promoters critical for DNA
CC       replication, DNA methylation, and class II flagellar biogenesis.
CC   -!- PTM: Phosphorylated by CckA. {ECO:0000305}.
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DR   EMBL; AE005673; AAK24997.1; -; Genomic_DNA.
DR   EMBL; AF021339; AAC05479.1; -; Genomic_DNA.
DR   PIR; A87625; A87625.
DR   RefSeq; NP_421829.1; NC_002696.2.
DR   RefSeq; WP_010920871.1; NC_002696.2.
DR   AlphaFoldDB; P0CAW8; -.
DR   SMR; P0CAW8; -.
DR   DIP; DIP-60565N; -.
DR   IntAct; P0CAW8; 3.
DR   STRING; 190650.CC_3035; -.
DR   EnsemblBacteria; AAK24997; AAK24997; CC_3035.
DR   KEGG; ccr:CC_3035; -.
DR   PATRIC; fig|190650.5.peg.3039; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_5; -.
DR   OMA; RSFIVIN; -.
DR   BioCyc; CAULO:CC3035-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   CollecTF; EXPREG_000008c0; -.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IPI:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IPI:CollecTF.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IMP:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..231
FT                   /note="Cell cycle transcriptional regulator CtrA"
FT                   /id="PRO_0000081084"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..223
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   231 AA;  25796 MW;  BB812AF6EDAADBF8 CRC64;
     MRVLLIEDDS ATAQTIELML KSEGFNVYTT DLGEEGVDLG KIYDYDLILL DLNLPDMSGI
     DVLRTLRVAK INTPIMILSG SSEIDTKVKT FAGGADDYMT KPFHKDEMIA RIHAVVRRSK
     GHAQSVIKTG DIVVNLDAKT VEVNGNRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
     GMDEPELKII DVFICKLRKK LAASAHGKHH IETVWGRGYV LRDPNEQVNA A