ID   CTRA_CAUVN              Reviewed;         231 AA.
AC   B8H358; Q45994;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Cell cycle transcriptional regulator CtrA;
DE   AltName: Full=Response regulator SokA;
GN   Name=ctrA; Synonyms=sokA; OrderedLocusNames=CCNA_03130;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8548829; DOI=10.1016/s0092-8674(00)80995-2;
RA   Quon K.C., Marczynski G.T., Shapiro L.;
RT   "Cell cycle control by an essential bacterial two-component signal
RT   transduction protein.";
RL   Cell 84:83-93(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
RN   [3]
RP   DEGRADATION, AND MUTAGENESIS OF ASP-51.
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=9755166; DOI=10.1093/emboj/17.19.5658;
RA   Jenal U., Fuchs T.;
RT   "An essential protease involved in bacterial cell-cycle control.";
RL   EMBO J. 17:5658-5669(1998).
CC   -!- FUNCTION: Forms part of a two-component regulatory system CtrA/CckA
CC       that controls multiple events in the cell cycle, including cell
CC       division, stalk synthesis and cell cycle-specific transcription. Binds
CC       to a group of cell cycle-regulated promoters critical for DNA
CC       replication, DNA methylation, and class II flagellar biogenesis.
CC   -!- PTM: Phosphorylated by CckA. Degraded by the ClpXP protease
CC       (PubMed:9755166). {ECO:0000269|PubMed:9755166}.
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DR   EMBL; U39559; AAA93080.1; -; Genomic_DNA.
DR   EMBL; CP001340; ACL96595.1; -; Genomic_DNA.
DR   RefSeq; WP_010920871.1; NC_011916.1.
DR   RefSeq; YP_002518503.1; NC_011916.1.
DR   AlphaFoldDB; B8H358; -.
DR   SMR; B8H358; -.
DR   PRIDE; B8H358; -.
DR   EnsemblBacteria; ACL96595; ACL96595; CCNA_03130.
DR   GeneID; 7330968; -.
DR   KEGG; ccs:CCNA_03130; -.
DR   PATRIC; fig|565050.3.peg.3056; -.
DR   HOGENOM; CLU_000445_30_1_5; -.
DR   OMA; RSFIVIN; -.
DR   OrthoDB; 1020672at2; -.
DR   PhylomeDB; B8H358; -.
DR   PRO; PR:B8H358; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..231
FT                   /note="Cell cycle transcriptional regulator CtrA"
FT                   /id="PRO_0000378311"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..223
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MUTAGEN         51
FT                   /note="D->E: Relies on ClpXP for degradation."
FT                   /evidence="ECO:0000305|PubMed:9755166"
SQ   SEQUENCE   231 AA;  25796 MW;  BB812AF6EDAADBF8 CRC64;
     MRVLLIEDDS ATAQTIELML KSEGFNVYTT DLGEEGVDLG KIYDYDLILL DLNLPDMSGI
     DVLRTLRVAK INTPIMILSG SSEIDTKVKT FAGGADDYMT KPFHKDEMIA RIHAVVRRSK
     GHAQSVIKTG DIVVNLDAKT VEVNGNRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
     GMDEPELKII DVFICKLRKK LAASAHGKHH IETVWGRGYV LRDPNEQVNA A