ID   CTRB_NEIMB              Reviewed;         387 AA.
AC   P32014;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Capsule polysaccharide export inner-membrane protein CtrB;
GN   Name=ctrB; OrderedLocusNames=NMB0072;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B1940 / Serogroup B;
RX   PubMed=1659649; DOI=10.1111/j.1365-2958.1991.tb01899.x;
RA   Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.;
RT   "Evidence for a common molecular origin of the capsule gene loci in Gram-
RT   negative bacteria expressing group II capsular polysaccharides.";
RL   Mol. Microbiol. 5:1251-1263(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: May form an ATP-driven capsule polysaccharide export
CC       apparatus, in association with the CtrC and CtrD proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BexC/CtrB/KpsE family. {ECO:0000305}.
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DR   EMBL; M57677; AAA25451.1; -; Genomic_DNA.
DR   EMBL; AE002098; AAF40539.1; -; Genomic_DNA.
DR   PIR; S15221; S15221.
DR   RefSeq; NP_273136.1; NC_003112.2.
DR   RefSeq; WP_002215287.1; NC_003112.2.
DR   AlphaFoldDB; P32014; -.
DR   SMR; P32014; -.
DR   STRING; 122586.NMB0072; -.
DR   TCDB; 8.A.4.2.1; the cytoplasmic membrane-periplasmic auxiliary-2 (mpa2) family.
DR   PaxDb; P32014; -.
DR   EnsemblBacteria; AAF40539; AAF40539; NMB0072.
DR   GeneID; 61282338; -.
DR   KEGG; nme:NMB0072; -.
DR   PATRIC; fig|122586.8.peg.106; -.
DR   HOGENOM; CLU_027864_0_1_4; -.
DR   OMA; LYMAFIA; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005705; BexC_CtrB_KpsE_VexD.
DR   TIGRFAMs; TIGR01010; BexC_CtrB_KpsE; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell inner membrane; Cell membrane;
KW   Membrane; Polysaccharide transport; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..387
FT                   /note="Capsule polysaccharide export inner-membrane protein
FT                   CtrB"
FT                   /id="PRO_0000079498"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   387 AA;  43392 MW;  8C20C87431DF951E CRC64;
     MSEQLPVAVA TETKAERKKP KKKSWIKKLS PLFWVTVIIP TVISLVYFGF FASDRFTSQS
     SFVVRSPKSQ SSLNGLGAIL QGTGFARAQD DIYTVGEYMR SRSSLDELRK ILPVREFYET
     KGDAFSRFNG FGFRGEEEAF YQYYKNQVMI NFDTVSGIST LNVTSFDALE SKKINEALLK
     QGEALINQLN DRARADTVRY AEEVVKTAAE RVKEASQNLT DYRIANGVFD LKAQSEVQMG
     LVSKLQDELI VIQTQLDQVK AVTPENPQIP GLQAREQSLR KEIDQQLRAI SGGGHSSLSN
     QAAEYQRVYL ENQLAEQQLA AAMTSLESAK VEADRQQLYL EVISQPSLPD LAHEPKRLYN
     IVATLIIGLM VYGILSLLTA SIREHKN