ID   CTRC_NEIMB              Reviewed;         265 AA.
AC   P32015;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Capsule polysaccharide export inner-membrane protein CtrC;
GN   Name=ctrC; OrderedLocusNames=NMB0073;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B1940 / Serogroup B;
RX   PubMed=1659649; DOI=10.1111/j.1365-2958.1991.tb01899.x;
RA   Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.;
RT   "Evidence for a common molecular origin of the capsule gene loci in Gram-
RT   negative bacteria expressing group II capsular polysaccharides.";
RL   Mol. Microbiol. 5:1251-1263(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: May form an ATP-driven capsule polysaccharide export
CC       apparatus, in association with the CtrB and CtrD proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; M57677; AAA25452.1; -; Genomic_DNA.
DR   EMBL; AE002098; AAF40540.1; -; Genomic_DNA.
DR   PIR; G81241; G81241.
DR   PIR; S15222; S15222.
DR   RefSeq; NP_273137.1; NC_003112.2.
DR   RefSeq; WP_002215286.1; NC_003112.2.
DR   AlphaFoldDB; P32015; -.
DR   SMR; P32015; -.
DR   STRING; 122586.NMB0073; -.
DR   PaxDb; P32015; -.
DR   EnsemblBacteria; AAF40540; AAF40540; NMB0073.
DR   GeneID; 61282339; -.
DR   KEGG; nme:NMB0073; -.
DR   PATRIC; fig|122586.8.peg.107; -.
DR   HOGENOM; CLU_060703_5_1_4; -.
DR   OMA; AFRQVQP; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IBA:GO_Central.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR000412; ABC_2_transport.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   PRINTS; PR00164; ABC2TRNSPORT.
DR   PROSITE; PS51012; ABC_TM2; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell inner membrane; Cell membrane;
KW   Membrane; Polysaccharide transport; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..265
FT                   /note="Capsule polysaccharide export inner-membrane protein
FT                   CtrC"
FT                   /id="PRO_0000182980"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          37..258
FT                   /note="ABC transmembrane type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
FT   CONFLICT        61
FT                   /note="R -> K (in Ref. 1; AAA25452)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   265 AA;  30196 MW;  FD117A37E0B16A09 CRC64;
     MKALHKTSFW ESLAIQRRVI GALLMREIIT RYGRNNIGFL WLFVEPLLMT FVIVLMWKFL
     RADRYSTLNI VAFAITGYPM LMMWRNASKR AVGSISSNAS LLYHRNVRVL DTILARMILE
     IAGATIAQIV IMAVLIAIGW IEMPADMFYM LMAWLLMAFF AIGLGLVICS IAFNFEPFGK
     IWGTLTFVMM PLSGAFFFVH NLPPKVQEYA LMIPMVHGTE MFRAGYFGSD VITYENPWYI
     VLCNLVLLLF GLAMVSKFSK GVEPQ