CTRL_HUMAN
ID CTRL_HUMAN Reviewed; 264 AA.
AC P40313;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Chymotrypsin-like protease CTRL-1;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN Name=CTRL; Synonyms=CTRL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8268911; DOI=10.1093/hmg/2.10.1589;
RA Larsen F., Solheim J., Kristensen T., Kolstoe A.-B., Prydz H.;
RT "A tight cluster of five unrelated human genes on chromosome 16q22.1.";
RL Hum. Mol. Genet. 2:1589-1595(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P40313; O00501: CLDN5; NbExp=3; IntAct=EBI-7883667, EBI-18400628;
CC P40313; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-7883667, EBI-18304435;
CC P40313; Q969F0: FATE1; NbExp=3; IntAct=EBI-7883667, EBI-743099;
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; X71874; CAA50710.1; -; Genomic_DNA.
DR EMBL; X71877; CAA50711.1; -; mRNA.
DR EMBL; BC063475; AAH63475.1; -; mRNA.
DR CCDS; CCDS10852.1; -.
DR PIR; I38136; I38136.
DR RefSeq; NP_001898.1; NM_001907.2.
DR AlphaFoldDB; P40313; -.
DR SMR; P40313; -.
DR BioGRID; 107886; 15.
DR IntAct; P40313; 7.
DR MINT; P40313; -.
DR STRING; 9606.ENSP00000458537; -.
DR BindingDB; P40313; -.
DR ChEMBL; CHEMBL4873; -.
DR MEROPS; S01.256; -.
DR GlyGen; P40313; 1 site.
DR iPTMnet; P40313; -.
DR PhosphoSitePlus; P40313; -.
DR BioMuta; CTRL; -.
DR DMDM; 729224; -.
DR EPD; P40313; -.
DR jPOST; P40313; -.
DR MassIVE; P40313; -.
DR PaxDb; P40313; -.
DR PeptideAtlas; P40313; -.
DR PRIDE; P40313; -.
DR ProteomicsDB; 55361; -.
DR Antibodypedia; 15944; 207 antibodies from 28 providers.
DR DNASU; 1506; -.
DR Ensembl; ENST00000574481.6; ENSP00000458537.2; ENSG00000141086.18.
DR GeneID; 1506; -.
DR KEGG; hsa:1506; -.
DR MANE-Select; ENST00000574481.6; ENSP00000458537.2; NM_001907.3; NP_001898.1.
DR UCSC; uc002euw.4; human.
DR CTD; 1506; -.
DR DisGeNET; 1506; -.
DR GeneCards; CTRL; -.
DR HGNC; HGNC:2524; CTRL.
DR HPA; ENSG00000141086; Tissue enriched (pancreas).
DR MIM; 118888; gene.
DR neXtProt; NX_P40313; -.
DR PharmGKB; PA27025; -.
DR VEuPathDB; HostDB:ENSG00000141086; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000154494; -.
DR HOGENOM; CLU_006842_7_6_1; -.
DR InParanoid; P40313; -.
DR OMA; APAMYTR; -.
DR OrthoDB; 1522379at2759; -.
DR PhylomeDB; P40313; -.
DR PathwayCommons; P40313; -.
DR SignaLink; P40313; -.
DR BioGRID-ORCS; 1506; 13 hits in 1061 CRISPR screens.
DR ChiTaRS; CTRL; human.
DR GeneWiki; CTRL_(gene); -.
DR GenomeRNAi; 1506; -.
DR Pharos; P40313; Tchem.
DR PRO; PR:P40313; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P40313; protein.
DR Bgee; ENSG00000141086; Expressed in body of pancreas and 95 other tissues.
DR ExpressionAtlas; P40313; baseline and differential.
DR Genevisible; P40313; HS.
DR GO; GO:0005615; C:extracellular space; IDA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0008236; F:serine-type peptidase activity; IDA:GO_Central.
DR GO; GO:0030163; P:protein catabolic process; IC:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW Serine protease; Signal; Zymogen.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..33
FT /note="Activation peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000027660"
FT CHAIN 34..264
FT /note="Chymotrypsin-like protease CTRL-1"
FT /id="PRO_0000027661"
FT DOMAIN 34..262
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 75
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 121
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 214
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 19..141
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 60..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 155..220
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 187..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 210..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT VARIANT 150
FT /note="T -> I (in dbSNP:rs11552953)"
FT /id="VAR_051834"
FT VARIANT 173
FT /note="H -> R (in dbSNP:rs1134760)"
FT /id="VAR_021939"
SQ SEQUENCE 264 AA; 28002 MW; 3F629F02FA6DDFB4 CRC64;
MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS LQDSSGFHFC
GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ VLSVSRAITH PSWNSTTMNN
DVTLLKLASP AQYTTRISPV CLASSNEALT EGLTCVTTGW GRLSGVGNVT PAHLQQVALP
LVTVNQCRQY WGSSITDSMI CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN
VRAPAVYTRV SKFSTWINQV IAYN
