CTS32_CAEEL
ID CTS32_CAEEL Reviewed; 517 AA.
AC P52714;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 07-APR-2021, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Serine carboxypeptidase ctsa-3.2 {ECO:0000305};
DE EC=3.4.16.- {ECO:0000250|UniProtKB:P52719};
DE Flags: Precursor;
GN Name=ctsa-3.2 {ECO:0000312|WormBase:C08H9.1};
GN ORFNames=C08H9.1 {ECO:0000312|WormBase:C08H9.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-269, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-269, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
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DR EMBL; BX284602; CAA91143.2; -; Genomic_DNA.
DR PIR; T19106; T19106.
DR RefSeq; NP_496134.1; NM_063733.1.
DR AlphaFoldDB; P52714; -.
DR SMR; P52714; -.
DR STRING; 6239.C08H9.1; -.
DR ESTHER; caeel-c08h9.1; Carboxypeptidase_S10.
DR MEROPS; S10.A56; -.
DR iPTMnet; P52714; -.
DR PaxDb; P52714; -.
DR EnsemblMetazoa; C08H9.1.1; C08H9.1.1; WBGene00007462.
DR UCSC; C08H9.1; c. elegans.
DR WormBase; C08H9.1; CE54048; WBGene00007462; ctsa-3.2.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_13_3_1; -.
DR InParanoid; P52714; -.
DR OrthoDB; 625787at2759; -.
DR PhylomeDB; P52714; -.
DR Reactome; R-CEL-2132295; MHC class II antigen presentation.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR PRO; PR:P52714; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00007462; Expressed in larva and 1 other tissue.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 1: Evidence at protein level;
KW Carboxypeptidase; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..517
FT /note="Serine carboxypeptidase ctsa-3.2"
FT /id="PRO_0000120568"
FT ACT_SITE 172
FT /evidence="ECO:0000250|UniProtKB:P52719"
FT ACT_SITE 418
FT /evidence="ECO:0000250|UniProtKB:P52719"
FT ACT_SITE 485
FT /evidence="ECO:0000250|UniProtKB:P52719"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
SQ SEQUENCE 517 AA; 59026 MW; 53F54135346B7054 CRC64;
MWWTSLVFSV LLFDLIFISN CDYIHLPGNS DIPDLKLQSG YLNANENGTQ KMFYFLLEAR
DIPVGEASLI IWFNGGPGCS SLSAFFEEFG PLYVNFGGKS LFENVHSWYH KANILFLESP
IGVGFSYDTE QSNFTKVNDD SIAEQNFNSV IDFFQRKHSS YVNHDFFIAA ESYGGVYGPM
LSALVVDSIS KREFPNENFK GLIIGNGFMN VKLSTNTMIL WSAYHDRTSP DEWDEIKEKC
ATSGAHDVDY YDFMQFMKTT NKMDYLADNS TECGRLIEPL LGQFSETFDG YDFFNYYHDC
YTNFSIPNAT DPIKETLAQI PRRRISALFN KHSTDGQASY RCWADDALHK YLNLKEVQNA
LGIDRAWKDR KKKWEVCNMP IYDQYVMTHQ DMTPFFSKIF DKFTGPAFRV LIYSGDIDTA
CNYLADGYFV RDLASIHGFK KTLKHGPWYH SEHKVIAGNF MRYEGANHLG SKLSIDVVTV
KGSGHFVPLD RPGPALQMVH NFLTGKPGKM TNYTSPV
