CTSEL_MOUSE
ID CTSEL_MOUSE Reviewed; 775 AA.
AC A0A0A6YXX9; B2RW93; Q3V2N6;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 04-FEB-2015, sequence version 1.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=Cation channel sperm-associated protein subunit epsilon-like protein {ECO:0000305};
DE Short=CatSper-epsilon-like {ECO:0000305};
DE Short=CatSperepsilon-like {ECO:0000305};
DE Flags: Precursor;
GN Name=Catspere2 {ECO:0000312|MGI:MGI:5589632};
GN Synonyms=Gm16432 {ECO:0000312|MGI:MGI:5589632};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0A0A6YXX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0A0A6YXX9-2; Sequence=VSP_058976, VSP_058977;
CC -!- SIMILARITY: Belongs to the CATSPERD family. {ECO:0000305}.
CC -!- CAUTION: Although related to the CATSPERD family, it is unclear whether
CC the protein is part of a Catsper complex. {ECO:0000305}.
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DR EMBL; AK131684; BAE20761.1; -; mRNA.
DR EMBL; AC113044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC119928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC147679; AAI47680.1; -; mRNA.
DR EMBL; BC147686; AAI47687.1; -; mRNA.
DR CCDS; CCDS35802.1; -. [A0A0A6YXX9-2]
DR RefSeq; NP_001030071.2; NM_001034899.3. [A0A0A6YXX9-2]
DR AlphaFoldDB; A0A0A6YXX9; -.
DR SMR; A0A0A6YXX9; -.
DR STRING; 10090.ENSMUSP00000091828; -.
DR GlyGen; A0A0A6YXX9; 2 sites.
DR PaxDb; A0A0A6YXX9; -.
DR ProteomicsDB; 283979; -. [A0A0A6YXX9-1]
DR ProteomicsDB; 283980; -. [A0A0A6YXX9-2]
DR Ensembl; ENSMUST00000094273; ENSMUSP00000091828; ENSMUSG00000091476. [A0A0A6YXX9-2]
DR Ensembl; ENSMUST00000192146; ENSMUSP00000142187; ENSMUSG00000091476. [A0A0A6YXX9-1]
DR Ensembl; ENSMUST00000239155; ENSMUSP00000158918; ENSMUSG00000091476. [A0A0A6YXX9-1]
DR GeneID; 545391; -.
DR KEGG; mmu:545391; -.
DR UCSC; uc007duv.2; mouse.
DR CTD; 545391; -.
DR MGI; MGI:5589632; Catspere2.
DR VEuPathDB; HostDB:ENSMUSG00000091476; -.
DR eggNOG; ENOG502R8SD; Eukaryota.
DR GeneTree; ENSGT00940000162691; -.
DR HOGENOM; CLU_014273_0_0_1; -.
DR OrthoDB; 213907at2759; -.
DR ChiTaRS; Catspere2; mouse.
DR PRO; PR:A0A0A6YXX9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; A0A0A6YXX9; protein.
DR Bgee; ENSMUSG00000091476; Expressed in spermatocyte and 34 other tissues.
DR ExpressionAtlas; A0A0A6YXX9; baseline and differential.
DR Genevisible; Q3V2N6; MM.
DR GO; GO:0036128; C:CatSper complex; IEA:InterPro.
DR GO; GO:0097228; C:sperm principal piece; ISO:MGI.
DR InterPro; IPR028751; CATSPERD/E.
DR PANTHER; PTHR33722; PTHR33722; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..775
FT /note="Cation channel sperm-associated protein subunit
FT epsilon-like protein"
FT /evidence="ECO:0000255"
FT /id="PRO_5002024633"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 144..145
FT /note="IV -> SS (in isoform 2)"
FT /id="VSP_058976"
FT VAR_SEQ 146..775
FT /note="Missing (in isoform 2)"
FT /id="VSP_058977"
FT CONFLICT 15
FT /note="S -> N (in Ref. 1; BAE20761)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="E -> K (in Ref. 1; BAE20761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 775 AA; 89594 MW; DDE7F73CB5A626E4 CRC64;
MLARRVVAAL LLWLSCCVSA LWRYYINSQD YSIFSTRSSI KLEYEGNSFV SWKIPESCKV
ENNTSPKTTL HCKRAGIHTI EPIARNQEVE RHLTVDNSYI CYLWYFTVVD VYYNLSQIVT
IWVYDPESAS TEELIRTAKK PSLIVTIWVY DPESASTEEL IWTAKKPSLN SLVLTKQMNT
LGQRPFIFTV EKRLAYHPGP LTSEGTWVIH LPMSTDDIAK VIQGNNVDFQ DCRIADLHFL
LTFPMEIVLE PPGYLPLTLP PGSPLMLSWD TCISTFALLA TDQETFQTND SFQTWTRVRA
PPGILSDAQR HSLRDVLVFR TGILFLVETT VYLKTDNEFI KLDKSRGISE TGILGLSKRR
WCQIRYLYKS AAGRTFVLAW TKSEVYGGFG KFKFMRFTTT SRLKYLLKLP PTDTLEIITV
EYSWHPLEAA ALLSHCSVCT TTKNIRMVIF NSAYFSWKLQ DFELQVPKEA KLEYRFLYSA
MPDIIVWDEH QVYYGYRNFA VFGTITTASG ETNLSSLSQG SNIHQVLTDS IGNVVVKMEN
NVMFYIKADI TEAVILHTWV NTTAKTGLFF DKSFEVCILY YNENLDEKYQ LQTQPYPLIL
ELQSINKDLG DWCPYLAFQH NIHSQFYHMD KGESLTIWSQ IVYPENRGLY IVLEHYGMRI
LTWTQNIEYE IASGFCTKTL ITRFFQTTNY ELVDNYYQLQ KENTGLLVFQ FRPSEFSRMC
PTAKPVFEID VGCDSSKHIM VQGFNRSGCQ RRDFSYVIDK ELLRESLSDN LVRNL
