CTSG1_MOUSE
ID CTSG1_MOUSE Reviewed; 1151 AA.
AC E9Q355; E9PW02; E9QAY8; Q3V0A1; Q8C9D6; Q8CAA4; Q8R5F0;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Cation channel sperm-associated protein subunit gamma 1;
DE Flags: Precursor;
GN Name=Catsperg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=E9Q355-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9Q355-2; Sequence=VSP_042991;
CC Name=3;
CC IsoId=E9Q355-3; Sequence=VSP_042983, VSP_042991, VSP_042994;
CC Name=4;
CC IsoId=E9Q355-4; Sequence=VSP_042986, VSP_042987, VSP_042989,
CC VSP_042990;
CC Name=5;
CC IsoId=E9Q355-5; Sequence=VSP_042987, VSP_042988, VSP_042992,
CC VSP_042993;
CC Name=6;
CC IsoId=E9Q355-6; Sequence=VSP_042984, VSP_042985, VSP_042989,
CC VSP_042990;
CC -!- SIMILARITY: Belongs to the CATSPERG family. {ECO:0000305}.
CC -!- CAUTION: Despite its name, it is unclear whether the protein is part of
CC some Catsper complex: in contrast to Catsperg2, it has not been
CC identified in the Catsper complex and its expression is not restricted
CC to testis tissues. {ECO:0000305}.
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DR EMBL; AK039202; BAC30276.1; -; mRNA.
DR EMBL; AK042364; BAC31237.1; -; mRNA.
DR EMBL; AK133307; BAE21603.1; -; mRNA.
DR EMBL; AC164564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022688; AAH22688.1; -; mRNA.
DR CCDS; CCDS52170.1; -. [E9Q355-2]
DR CCDS; CCDS90197.1; -. [E9Q355-1]
DR RefSeq; NP_001158130.1; NM_001164658.1. [E9Q355-2]
DR RefSeq; XP_006540154.1; XM_006540091.3. [E9Q355-1]
DR AlphaFoldDB; E9Q355; -.
DR SMR; E9Q355; -.
DR STRING; 10090.ENSMUSP00000129837; -.
DR GlyGen; E9Q355; 1 site.
DR PhosphoSitePlus; E9Q355; -.
DR jPOST; E9Q355; -.
DR PaxDb; E9Q355; -.
DR PeptideAtlas; E9Q355; -.
DR PRIDE; E9Q355; -.
DR ProteomicsDB; 285223; -. [E9Q355-1]
DR ProteomicsDB; 285224; -. [E9Q355-2]
DR ProteomicsDB; 285225; -. [E9Q355-3]
DR ProteomicsDB; 285227; -. [E9Q355-5]
DR Ensembl; ENSMUST00000047846; ENSMUSP00000045233; ENSMUSG00000049676. [E9Q355-2]
DR Ensembl; ENSMUST00000069861; ENSMUSP00000067388; ENSMUSG00000049676. [E9Q355-4]
DR Ensembl; ENSMUST00000164653; ENSMUSP00000131827; ENSMUSG00000049676. [E9Q355-5]
DR Ensembl; ENSMUST00000169143; ENSMUSP00000129837; ENSMUSG00000049676. [E9Q355-1]
DR GeneID; 320225; -.
DR KEGG; mmu:320225; -.
DR UCSC; uc009gbe.1; mouse. [E9Q355-4]
DR UCSC; uc012fhe.1; mouse. [E9Q355-2]
DR CTD; 320225; -.
DR MGI; MGI:2443617; Catsperg1.
DR VEuPathDB; HostDB:ENSMUSG00000049676; -.
DR eggNOG; ENOG502QWAR; Eukaryota.
DR GeneTree; ENSGT00390000014139; -.
DR HOGENOM; CLU_010744_0_0_1; -.
DR InParanoid; E9Q355; -.
DR OMA; FFYEDRE; -.
DR OrthoDB; 110808at2759; -.
DR PhylomeDB; E9Q355; -.
DR TreeFam; TF337337; -.
DR BioGRID-ORCS; 320225; 1 hit in 58 CRISPR screens.
DR ChiTaRS; Catsperg1; mouse.
DR PRO; PR:E9Q355; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; E9Q355; protein.
DR Bgee; ENSMUSG00000049676; Expressed in testis and 56 other tissues.
DR ExpressionAtlas; E9Q355; baseline and differential.
DR Genevisible; E9Q355; MM.
DR GO; GO:0036128; C:CatSper complex; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0097228; C:sperm principal piece; IEA:InterPro.
DR InterPro; IPR028246; CATSPERG.
DR PANTHER; PTHR14327; PTHR14327; 1.
DR Pfam; PF15064; CATSPERG; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..1151
FT /note="Cation channel sperm-associated protein subunit
FT gamma 1"
FT /id="PRO_0000416886"
FT TOPO_DOM 39..1063
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1064..1084
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1085..1151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1113..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 356
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..120
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042983"
FT VAR_SEQ 1..6
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042984"
FT VAR_SEQ 57..276
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042985"
FT VAR_SEQ 57..91
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042986"
FT VAR_SEQ 110..276
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042987"
FT VAR_SEQ 380..399
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042988"
FT VAR_SEQ 401..418
FT /note="KNCSIDWATYITDERNLL -> THFFLCVWGIWNRRVVGL (in isoform
FT 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_042989"
FT VAR_SEQ 419..1151
FT /note="Missing (in isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_042990"
FT VAR_SEQ 534..586
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042991"
FT VAR_SEQ 534..546
FT /note="IWYFLEGGYDVYQ -> ELQDDHLHQHVPF (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042992"
FT VAR_SEQ 547..1151
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042993"
FT VAR_SEQ 974..1151
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042994"
FT CONFLICT E9Q355-6:178..179
FT /note="FL -> VCV (in Ref. 3; AAH22688)"
FT /evidence="ECO:0000305"
FT CONFLICT E9Q355-6:182
FT /note="W -> C (in Ref. 3; AAH22688)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1151 AA; 132352 MW; B9EDB8C0034A3F4B CRC64;
MVSRPAMSPV SPVWPRKPNL WAFWVLRLVL LLSLKSWAED TLQHCTWLLV LNKFEKVGLH
LSKDRFQDHE PIDTVAKVFQ KLTDSPIDPS ENYLSFPYYL QINFSCPGQN SEELARKGHL
MGMKPMVRIN YMYSVNFYRW EMENLQILME AAPMRSTGYC PAEAMCILNW YTPMPFKNGS
VVSSVDIYTN GIGPFIPKKR FYVNMNGFLK RDASGKSLFA IGYESLVLKS SHFRLSKSRP
LWYTVNHAPV FILGGFYDEK AILFSDSNFQ DYVLLELSID SCWVGSFYCP ILGFSATIHD
AIATESTLFI RQNQLVYYFT GTYSTLFDKS HGSSRWVRVL PSECIKRLCP VYFSGNGSEY
VLALTTGKNE GYIHIGTITD GLVSFEMVPD GWSVCEKLPG KNCSIDWATY ITDERNLLLL
VKIDSGQFYL VNFNTEFKTL NILYKIPEFI PEAKELDFLV LLDTVTYTNT PMTPKGLFFN
TLNNMLYIWG NFILQSYNRE EFIFLADFPK ESTIKYMVNS FKGQMAVVTE NEEIWYFLEG
GYDVYQVVPS QGWRTYLKLQ KMQKSPLYST NESLVSLFYQ DENLFQLVYL FDVGKERLVK
RLLPVGTLME YNLPKPFTVV NQGNYKMITF TNTCPFKAIH AVDVPKKQHA SRTESYVALP
PLVSESLGFH NNNTLAVYQG LVYYLLWLHS KYDKPYADPV HDPTWRWWQH KTKDKDYFFY
LFSNRLAAEG IYINMNAYQK LYNMSGDYGI PDLFFLDKGN WFTFTVVLLS HQDTFTSSDS
QGPTINVDKK LSLSLVLADP ECLSVTATRE FLLNRNTLLT KIKVIDKKRC SEQGMVGRNI
KKTSMLIKVL GAPGNCIQRT YLGDHIQGIR LVPIFIGCPP GKRLAFDVSY TIKHSEEINK
HYFDCVIKDA EMPCFLFRDL FQPFFLVQDL VTGDSGSFLG SYVLKVVGGG RTLNTIRDYT
EEEIFRYNSP LDTTNSLIWK TKVERTTEDK KFYIMSHESP GVEWLCLENS PCYDIIPQSI
YPPEFFFKLL VSNRGVDNST YCDYKLTFIV HIHGLPLSSK RSSFIVMVST SFFIALVVFY
ILFCLVWPHI VKAWVSFRWK IHNMMAPETY SSSSSSGGFT LHSHSSEGSF EGPSRPGTKE
DNVQAKRAKV A
