ID   CTSL2_DICDI             Reviewed;         567 AA.
AC   Q54GB2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=CTD small phosphatase-like protein 2;
DE            Short=CTDSP-like 2;
DE            EC=3.1.3.-;
GN   Name=ctdspl2; ORFNames=DDB_G0290365;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable phosphatase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTDSPL2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000162; EAL62309.1; -; Genomic_DNA.
DR   RefSeq; XP_635771.1; XM_630679.1.
DR   AlphaFoldDB; Q54GB2; -.
DR   SMR; Q54GB2; -.
DR   STRING; 44689.DDB0238050; -.
DR   PaxDb; Q54GB2; -.
DR   EnsemblProtists; EAL62309; EAL62309; DDB_G0290365.
DR   GeneID; 8627575; -.
DR   KEGG; ddi:DDB_G0290365; -.
DR   dictyBase; DDB_G0290365; ctdspl2.
DR   eggNOG; KOG1605; Eukaryota.
DR   HOGENOM; CLU_480972_0_0_1; -.
DR   InParanoid; Q54GB2; -.
DR   OMA; NNTEYQV; -.
DR   PRO; PR:Q54GB2; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR011948; Dullard_phosphatase.
DR   InterPro; IPR004274; FCP1_dom.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   Pfam; PF03031; NIF; 1.
DR   SMART; SM00577; CPDc; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR02251; HIF-SF_euk; 1.
DR   PROSITE; PS50969; FCP1; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..567
FT                   /note="CTD small phosphatase-like protein 2"
FT                   /id="PRO_0000331473"
FT   DOMAIN          386..544
FT                   /note="FCP1 homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00336"
FT   REGION          31..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..360
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  63950 MW;  1CCDEF91246F1ADF CRC64;
     MSSGLKTQTT IDILHDHSVE SSSDHLYILK QQQQHQHEDT DSPKKKKLRH QCEETSQYIV
     PSLNDEVDDL GHHHLHHHHV NNINNSLLKQ GLSALSSLSA SSTSSISPSS SQSSSPLKQS
     ERSIATSIDS MNDSTSSSSS SNNNNNFSSV PSHNIYTPSC LLSNLNNDTD SIIPNMNGST
     DGDGGDIRRE KVDENDEEVL CNDNHLSKDN EQEDNMVSFL NESNEEVIQT NNNNNNDNNN
     SSNICINNFC NINNNQQQQQ QQQQQQQNNV NSSIILEDSN KENKTESNNS NSNSNSSPSF
     FHNLQQHPTS AATTTTTTTT TITTTSATTS IIIKEDNSDD EIDDECDDES EEEEEDEEEF
     NPFLFIKQLA NATTMPPPVA LPPKEHSSPK ISLVLDLDET LVHCSTEPLE QPHLTFPVFF
     NNTEYQVFAK KRPFFEEFLH KVSDIFEVII FTASQEVYAN KLLNMIDPNN KIKYRLYRDS
     CVYVDGNYLK DLSVLGRDLK QVVIIDNSPQ SFGFQVDNGI PIESWFEDEN DKELLQLVPF
     LESLTNVEDV RPHIRDKFKL YQLISQA