CTSRG_HUMAN
ID CTSRG_HUMAN Reviewed; 1159 AA.
AC Q6ZRH7; A6NEG6; Q659E1;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Cation channel sperm-associated auxiliary subunit gamma {ECO:0000312|HGNC:HGNC:25243};
DE Flags: Precursor;
GN Name=CATSPERG {ECO:0000312|HGNC:HGNC:25243}; Synonyms=C19orf15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-661, AND VARIANT PRO-29.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1159.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Auxiliary component of the CatSper complex, a complex
CC involved in sperm cell hyperactivation. Sperm cell hyperactivation is
CC needed for sperm motility which is essential late in the preparation of
CC sperm for fertilization. {ECO:0000250|UniProtKB:C6KI89}.
CC -!- SUBUNIT: Component of the CatSper complex or CatSpermasome composed of
CC the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4
CC as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE,
CC CATSPERZ, C2CD6/CATSPERT, TMEM249, TMEM262 and EFCAB9. HSPA1 may be an
CC additional auxiliary complex member. The core complex members CATSPER1,
CC CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The
CC auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a
CC pavilion-like structure over the pore which stabilizes the complex
CC through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2
CC respectively. TMEM262/CATSPERH interacts with CATSPERB, further
CC stabilizing the complex. C2CD6/CATSPERT interacts at least with
CC CATSPERD and is required for targeting the CatSper complex in the
CC flagellar membrane. {ECO:0000250|UniProtKB:C6KI89}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane
CC {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the CATSPERG family. {ECO:0000305}.
CC -!- CAUTION: In mouse, Slco6c1 is an additional auxiliary subunit of the
CC CatSper complex. It is unclear if the related SLCO6A1 protein performs
CC the same role in non-rodent species. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC87333.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC005625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133023; CAH56391.1; ALT_TERM; mRNA.
DR EMBL; AK128220; BAC87333.1; ALT_INIT; mRNA.
DR CCDS; CCDS12514.2; -.
DR RefSeq; NP_067008.3; NM_021185.4.
DR RefSeq; XP_005259171.1; XM_005259114.4.
DR RefSeq; XP_005259172.1; XM_005259115.4.
DR RefSeq; XP_006723371.1; XM_006723308.3.
DR RefSeq; XP_006723374.1; XM_006723311.2.
DR RefSeq; XP_011525476.1; XM_011527174.2.
DR AlphaFoldDB; Q6ZRH7; -.
DR SMR; Q6ZRH7; -.
DR BioGRID; 121787; 3.
DR STRING; 9606.ENSP00000386962; -.
DR TCDB; 1.A.1.19.1; the voltage-gated ion channel (vic) superfamily.
DR GlyGen; Q6ZRH7; 2 sites.
DR iPTMnet; Q6ZRH7; -.
DR PhosphoSitePlus; Q6ZRH7; -.
DR BioMuta; CATSPERG; -.
DR DMDM; 215274173; -.
DR MassIVE; Q6ZRH7; -.
DR MaxQB; Q6ZRH7; -.
DR PaxDb; Q6ZRH7; -.
DR PeptideAtlas; Q6ZRH7; -.
DR PRIDE; Q6ZRH7; -.
DR ProteomicsDB; 68130; -.
DR Antibodypedia; 30031; 23 antibodies from 12 providers.
DR DNASU; 57828; -.
DR Ensembl; ENST00000409235.8; ENSP00000386962.3; ENSG00000099338.23.
DR GeneID; 57828; -.
DR KEGG; hsa:57828; -.
DR MANE-Select; ENST00000409235.8; ENSP00000386962.3; NM_021185.5; NP_067008.3.
DR UCSC; uc002oih.5; human.
DR CTD; 57828; -.
DR GeneCards; CATSPERG; -.
DR HGNC; HGNC:25243; CATSPERG.
DR HPA; ENSG00000099338; Tissue enriched (testis).
DR MIM; 613452; gene.
DR neXtProt; NX_Q6ZRH7; -.
DR OpenTargets; ENSG00000099338; -.
DR PharmGKB; PA165393235; -.
DR VEuPathDB; HostDB:ENSG00000099338; -.
DR eggNOG; ENOG502QWAR; Eukaryota.
DR GeneTree; ENSGT00390000014139; -.
DR InParanoid; Q6ZRH7; -.
DR OMA; FFYEDRE; -.
DR OrthoDB; 110808at2759; -.
DR PhylomeDB; Q6ZRH7; -.
DR TreeFam; TF337337; -.
DR PathwayCommons; Q6ZRH7; -.
DR Reactome; R-HSA-1300642; Sperm Motility And Taxes.
DR BioGRID-ORCS; 57828; 15 hits in 1065 CRISPR screens.
DR ChiTaRS; CATSPERG; human.
DR GenomeRNAi; 57828; -.
DR Pharos; Q6ZRH7; Tdark.
DR PRO; PR:Q6ZRH7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZRH7; protein.
DR Bgee; ENSG00000099338; Expressed in left testis and 96 other tissues.
DR ExpressionAtlas; Q6ZRH7; baseline and differential.
DR Genevisible; Q6ZRH7; HS.
DR GO; GO:0036128; C:CatSper complex; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0097228; C:sperm principal piece; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR028246; CATSPERG.
DR PANTHER; PTHR14327; PTHR14327; 1.
DR Pfam; PF15064; CATSPERG; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cilium; Developmental protein;
KW Differentiation; Disulfide bond; Flagellum; Glycoprotein; Membrane;
KW Reference proteome; Signal; Spermatogenesis; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..1159
FT /note="Cation channel sperm-associated auxiliary subunit
FT gamma"
FT /id="PRO_0000019565"
FT TOPO_DOM 36..1065
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT TRANSMEM 1066..1087
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT TOPO_DOM 1088..1159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT REGION 1139..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 426
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 574
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..105
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 159..165
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 288..343
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 394..402
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 638..860
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 806..834
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 882..1046
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 909..918
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT DISULFID 1010..1016
FT /evidence="ECO:0000250|UniProtKB:C6KI89"
FT VARIANT 29
FT /note="L -> P (in dbSNP:rs2302182)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_059631"
FT VARIANT 650
FT /note="S -> R (in dbSNP:rs3745953)"
FT /id="VAR_059632"
FT VARIANT 1137
FT /note="M -> T (in dbSNP:rs2286550)"
FT /id="VAR_059633"
FT CONFLICT 310..319
FT /note="RQNQLVYYFT -> HQLQGLLSRG (in Ref. 3; BAC87333)"
FT /evidence="ECO:0000305"
FT CONFLICT 943
FT /note="Q -> R (in Ref. 3; BAC87333)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1159 AA; 133032 MW; 6D11F84445A09CDF CRC64;
MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL NEFKRVGESG
VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK INYSCEEKPS EDLVRMGHLT
GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA APFRSKEPCM AEEVCSMSWY TPMPIKKGSV
VMRVDISSNG LGTFIPDKRF QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL
WHTVDQSPVL ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT
IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV YFHSNGSEYI
MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT TCSIIWSEYI AGEYTLLLLV
ESGYGNASKR FQVVSYNTAS DDLELLYHIP EFIPEARGLE FLMILGTESY TSTAMAPKGI
FCNPYNNLIF IWGNFLLQSS NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL
LEGSYRVYQL FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ
LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS PQRYTRQERY
RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY ADPVHDPTWR WWANNKQDQD
YYFFLASNWR SAGGVSIEMD SYEKIYNLES AYELPERIFL DKGTEYSFAI FLSAQGHSFR
TQSELGTAFQ LHSQVDVGVV LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS
GHHLMETSMT VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR
LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV VGGGPTLDSL
KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS HESPGIEWLC LENAPCYDNV
PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL TFLLHIHGLP LSPKRALFII MVSASVFVGL
VIFYIAFCLL WPLVVKGCTM IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS
RMTEDRAEPK EAVERQLMT
