CTSR_LACPL
ID CTSR_LACPL Reviewed; 155 AA.
AC Q88XZ6; F9UMJ5;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Transcriptional regulator CtsR;
DE AltName: Full=Class three stress gene repressor;
GN Name=ctsR; OrderedLocusNames=lp_1018;
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
RN [3]
RP FUNCTION, DNA-BINDING, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=19074391; DOI=10.1128/jb.01551-08;
RA Fiocco D., Collins M., Muscariello L., Hols P., Kleerebezem M., Msadek T.,
RA Spano G.;
RT "The Lactobacillus plantarum ftsH gene is a novel member of the CtsR stress
RT response regulon.";
RL J. Bacteriol. 191:1688-1694(2009).
CC -!- FUNCTION: Binds to the ftsH promoter region, leading to repression of
CC its expression. {ECO:0000269|PubMed:19074391}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Disruption leads to increased expression of ftsH,
CC indicating CtsR is a transcriptional repressor.
CC {ECO:0000269|PubMed:19074391}.
CC -!- SIMILARITY: Belongs to the CtsR family. {ECO:0000305}.
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DR EMBL; AL935263; CCC78434.1; -; Genomic_DNA.
DR RefSeq; WP_003644086.1; NC_004567.2.
DR RefSeq; YP_004888948.1; NC_004567.2.
DR AlphaFoldDB; Q88XZ6; -.
DR SMR; Q88XZ6; -.
DR STRING; 220668.lp_1018; -.
DR EnsemblBacteria; CCC78434; CCC78434; lp_1018.
DR GeneID; 57024681; -.
DR GeneID; 66448935; -.
DR KEGG; lpl:lp_1018; -.
DR PATRIC; fig|220668.9.peg.860; -.
DR eggNOG; COG4463; Bacteria.
DR HOGENOM; CLU_118139_0_0_9; -.
DR OMA; FRCAPSQ; -.
DR PhylomeDB; Q88XZ6; -.
DR BioCyc; LPLA220668:G1GW0-877-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.1200.150; -; 1.
DR Gene3D; 3.30.56.130; -; 1.
DR InterPro; IPR008463; CtsR.
DR InterPro; IPR041473; CtsR_C.
DR InterPro; IPR041908; CtsR_C_sf.
DR InterPro; IPR040465; CtsR_N.
DR InterPro; IPR041902; CtsR_N_sf.
DR PANTHER; PTHR40028; PTHR40028; 1.
DR Pfam; PF05848; CtsR; 1.
DR Pfam; PF17727; CtsR_C; 1.
DR PIRSF; PIRSF010607; Txn_repr_CtsR; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..155
FT /note="Transcriptional regulator CtsR"
FT /id="PRO_0000400425"
SQ SEQUENCE 155 AA; 17614 MW; 684CCB3D0D9BCDA6 CRC64;
MQSQNISDII EKYLKSILAD SEHVEIRRSE IADLFNVVPS QINYVIKTRF TIQNGYLVES
KRGGGGYIRI EKVNLVDDAD VLDALIQVIG DSITQRDAYA VVQSLYEDDV LNRREAQLIL
VAIDHETLGL TDRDLENSLR ARIIIGILNH LRYES
