ID   CTSR_STAA3              Reviewed;         153 AA.
AC   Q2FJB8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Transcriptional regulator CtsR;
GN   Name=ctsR; OrderedLocusNames=SAUSA300_0507;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Negative regulator of clpC, clpB and clpP transcription by
CC       binding directly and specifically to their promoter region.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CtsR family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD22257.1; -; Genomic_DNA.
DR   RefSeq; WP_000551762.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FJB8; -.
DR   SMR; Q2FJB8; -.
DR   EnsemblBacteria; ABD22257; ABD22257; SAUSA300_0507.
DR   KEGG; saa:SAUSA300_0507; -.
DR   HOGENOM; CLU_118139_0_0_9; -.
DR   OMA; FRCAPSQ; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1200.150; -; 1.
DR   Gene3D; 3.30.56.130; -; 1.
DR   InterPro; IPR008463; CtsR.
DR   InterPro; IPR041473; CtsR_C.
DR   InterPro; IPR041908; CtsR_C_sf.
DR   InterPro; IPR040465; CtsR_N.
DR   InterPro; IPR041902; CtsR_N_sf.
DR   PANTHER; PTHR40028; PTHR40028; 1.
DR   Pfam; PF05848; CtsR; 1.
DR   Pfam; PF17727; CtsR_C; 1.
DR   PIRSF; PIRSF010607; Txn_repr_CtsR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..153
FT                   /note="Transcriptional regulator CtsR"
FT                   /id="PRO_0000274129"
SQ   SEQUENCE   153 AA;  17842 MW;  2EA1D6892A9FE62A CRC64;
     MHNMSDIIEQ YIKRLFEESN EDVVEIQRAN IAQRFDCVPS QLNYVIKTRF TNEHGYEIES
     KRGGGGYIRI TKIENKDATG YINHLLQLIG PSISQQQAYY IIDGLLDKML INEREAKMIQ
     AVIDRETLSM DMVSRDIIRA NILKRLLPVI NYY