ID   CTSR_STAA8              Reviewed;         153 AA.
AC   Q2G0P8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transcriptional regulator CtsR;
GN   Name=ctsR; OrderedLocusNames=SAOUHSC_00502;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION.
RX   PubMed=15554981; DOI=10.1111/j.1365-2958.2004.04368.x;
RA   Frees D., Chastanet A., Qazi S., Soerensen K., Hill P., Msadek T.,
RA   Ingmer H.;
RT   "Clp ATPases are required for stress tolerance, intracellular replication
RT   and biofilm formation in Staphylococcus aureus.";
RL   Mol. Microbiol. 54:1445-1462(2004).
RN   [3]
RP   INDUCTION, AND INTERACTION WITH MCSA AND MCSB.
RC   STRAIN=SH1000;
RX   PubMed=22126623; DOI=10.1111/j.1574-6968.2011.02468.x;
RA   Sitthisak S., Kitti T., Boonyonying K., Wozniak D., Mongkolsuk S.,
RA   Jayaswal R.K.;
RT   "McsA and the roles of metal-binding motif in Staphylococcus aureus.";
RL   FEMS Microbiol. Lett. 327:126-133(2012).
CC   -!- FUNCTION: Negative regulator of clpC, clpB and clpP transcription by
CC       binding directly and specifically to their promoter region.
CC       {ECO:0000269|PubMed:15554981}.
CC   -!- SUBUNIT: Interacts with McsA and McsB. {ECO:0000269|PubMed:22126623}.
CC   -!- INDUCTION: Up-regulated by heavy metals such as Cu(2+) and Cd(2+), but
CC       Zn(2+) and Co(2+) have no effect. Forms part of an operon with mcsA,
CC       mcsB and clpC. {ECO:0000269|PubMed:22126623}.
CC   -!- SIMILARITY: Belongs to the CtsR family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD29651.1; -; Genomic_DNA.
DR   RefSeq; WP_000551762.1; NZ_LS483365.1.
DR   RefSeq; YP_499075.1; NC_007795.1.
DR   AlphaFoldDB; Q2G0P8; -.
DR   SMR; Q2G0P8; -.
DR   STRING; 1280.SAXN108_0575; -.
DR   EnsemblBacteria; ABD29651; ABD29651; SAOUHSC_00502.
DR   GeneID; 3920414; -.
DR   KEGG; sao:SAOUHSC_00502; -.
DR   PATRIC; fig|93061.5.peg.449; -.
DR   eggNOG; COG4463; Bacteria.
DR   HOGENOM; CLU_118139_0_0_9; -.
DR   OMA; FRCAPSQ; -.
DR   PRO; PR:Q2G0P8; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:1990170; P:stress response to cadmium ion; IDA:UniProtKB.
DR   GO; GO:1990169; P:stress response to copper ion; IDA:UniProtKB.
DR   Gene3D; 1.10.1200.150; -; 1.
DR   Gene3D; 3.30.56.130; -; 1.
DR   InterPro; IPR008463; CtsR.
DR   InterPro; IPR041473; CtsR_C.
DR   InterPro; IPR041908; CtsR_C_sf.
DR   InterPro; IPR040465; CtsR_N.
DR   InterPro; IPR041902; CtsR_N_sf.
DR   PANTHER; PTHR40028; PTHR40028; 1.
DR   Pfam; PF05848; CtsR; 1.
DR   Pfam; PF17727; CtsR_C; 1.
DR   PIRSF; PIRSF010607; Txn_repr_CtsR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..153
FT                   /note="Transcriptional regulator CtsR"
FT                   /id="PRO_0000274128"
SQ   SEQUENCE   153 AA;  17842 MW;  2EA1D6892A9FE62A CRC64;
     MHNMSDIIEQ YIKRLFEESN EDVVEIQRAN IAQRFDCVPS QLNYVIKTRF TNEHGYEIES
     KRGGGGYIRI TKIENKDATG YINHLLQLIG PSISQQQAYY IIDGLLDKML INEREAKMIQ
     AVIDRETLSM DMVSRDIIRA NILKRLLPVI NYY