CTSR_STAAS
ID CTSR_STAAS Reviewed; 153 AA.
AC Q6GBW6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Transcriptional regulator CtsR;
GN Name=ctsR; OrderedLocusNames=SAS0479;
OS Staphylococcus aureus (strain MSSA476).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282459;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSSA476;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Negative regulator of clpC, clpB and clpP transcription by
CC binding directly and specifically to their promoter region.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CtsR family. {ECO:0000305}.
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DR EMBL; BX571857; CAG42254.1; -; Genomic_DNA.
DR RefSeq; WP_000551762.1; NC_002953.3.
DR AlphaFoldDB; Q6GBW6; -.
DR SMR; Q6GBW6; -.
DR KEGG; sas:SAS0479; -.
DR HOGENOM; CLU_118139_0_0_9; -.
DR OMA; FRCAPSQ; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.1200.150; -; 1.
DR Gene3D; 3.30.56.130; -; 1.
DR InterPro; IPR008463; CtsR.
DR InterPro; IPR041473; CtsR_C.
DR InterPro; IPR041908; CtsR_C_sf.
DR InterPro; IPR040465; CtsR_N.
DR InterPro; IPR041902; CtsR_N_sf.
DR PANTHER; PTHR40028; PTHR40028; 1.
DR Pfam; PF05848; CtsR; 1.
DR Pfam; PF17727; CtsR_C; 1.
DR PIRSF; PIRSF010607; Txn_repr_CtsR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..153
FT /note="Transcriptional regulator CtsR"
FT /id="PRO_0000274135"
SQ SEQUENCE 153 AA; 17842 MW; 2EA1D6892A9FE62A CRC64;
MHNMSDIIEQ YIKRLFEESN EDVVEIQRAN IAQRFDCVPS QLNYVIKTRF TNEHGYEIES
KRGGGGYIRI TKIENKDATG YINHLLQLIG PSISQQQAYY IIDGLLDKML INEREAKMIQ
AVIDRETLSM DMVSRDIIRA NILKRLLPVI NYY