CTTB2_PLEMO
ID CTTB2_PLEMO Reviewed; 1663 AA.
AC Q2QLB3;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Cortactin-binding protein 2;
DE Short=CortBP2;
GN Name=CTTNBP2; Synonyms=CORTBP2;
OS Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini;
OC Pitheciidae; Callicebinae; Plecturocebus.
OX NCBI_TaxID=9523;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A.,
RA Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J.,
RA Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J., Hansen N.,
RA Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Kwong P., Laric P.,
RA Larson S., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B.,
RA Margulies E.H., Masiello C., Maskeri B., McDowell J., Mojidi H.A.,
RA Mullikin J.C., Oestreicher J.S., Park M., Portnoy M.E., Prasad A., Puri O.,
RA Reddix-Dugue N., Schandler K., Schueler M.G., Sison C., Stantripop S.,
RA Stephen E., Taye A., Thomas J.W., Thomas P.J., Tsipouri V., Ung L.,
RA Vogt J.L., Wetherby K.D., Young A., Green E.D.;
RT "NISC comparative sequencing initiative.";
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the dendritic spine distribution of CTTN/cortactin
CC in hippocampal neurons, thus controls dendritic spinogenesis and
CC dendritic spine maintenance. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN,
CC STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic
CC spine distribution of STRN and STRN4 in hippocampal neurons. Activation
CC of glutamate receptors weakens the interaction with STRN and STRN4.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}. Cell
CC projection, dendritic spine {ECO:0000250}. Note=Remains associated with
CC dendritic spines even after glutamate stimulation. {ECO:0000250}.
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DR EMBL; DP000019; ABB89796.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2QLB3; -.
DR SMR; Q2QLB3; -.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR019131; Cortactin-binding_p2_N.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF09727; CortBP2; 2.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 3: Inferred from homology;
KW ANK repeat; Cell projection; Coiled coil; Cytoplasm; Methylation;
KW Phosphoprotein; Repeat; Synapse.
FT CHAIN 1..1663
FT /note="Cortactin-binding protein 2"
FT /id="PRO_0000227000"
FT REPEAT 709..739
FT /note="ANK 1"
FT REPEAT 743..772
FT /note="ANK 2"
FT REPEAT 776..805
FT /note="ANK 3"
FT REPEAT 809..838
FT /note="ANK 4"
FT REPEAT 842..871
FT /note="ANK 5"
FT REPEAT 912..942
FT /note="ANK 6"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 119..275
FT /evidence="ECO:0000255"
FT COMPBIAS 380..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..557
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1647..1663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 498
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:B9EJA2"
FT MOD_RES 1524
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ74"
SQ SEQUENCE 1663 AA; 180960 MW; 654C7B7735856746 CRC64;
MATDGASCEP DLSRAPEDAA GATAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE
ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK KPVCTNPLSI LEAVMAHCRK
MQERMSAQLA AAESRQKKLE MEKLQLQALE QEHKKLAARL EEERGKNKQV VLMLVKECKQ
LSGRVIEEAQ KLKDVMAKLE EEKKKTNELE EELSAEKQRS TEMEAQMEKQ LSEFDTEREQ
LRAKLNREEA HTTDLKEEID KMKKMIEQLK KGGDSKPSLS LPRKTKDRRL VSISVGTEGT
VTRSVACQTD LVTESADHVK KLPLTMPVKP STGSPLASAN AKGSVCTSAA MARPSIDRQP
SHGDLIGVSV PAFPPSSANR IEENGPSTDS TPDPTSSTPL LSSNAAPPTA QTPGITPQNS
QAPPMHSLHS PCANASLHPG LNPRIQAARF RFQGNANDPD QNGNTTQSPP SRDVSPTSRD
NLVAKQLARN TVTQALSRFT GPQAGAPPRP GAPPTGDVGT HPSVGRTSVK THGVARVDRG
NPPPIPPKKP GLSQTPSPPH PQLKVIIDSS RASNTGAKGD NKTVASPPSS LPQGNRVINE
ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA CSDSSLVIPT
TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ
GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLSAEAQV NAADTNGFTP
LCAAAAQGHF ECVELLIAYD ANINHAAGGG QTPLYLACKN GNKECIKLLL EAGTDRCVKT
TDGWTPVHAA VDTGNVDSLK LLMYHRVPAH GNSFSEEESE SGVFDLDGEE ESPEGKSKPV
VTADLINHAN REGWTAAHIA AAKGFKNCLE ILCRHGGLEP ERRDKCNRTV HDVATDDCKH
LLENLNALKI PLRISVGEIE PSDYGSDDFE CENTICSLNI RKQTSWDDFS KAVNQALTNH
FQAISSDGWW SLEDVTCNNT TDSNIGLSAR SIRSITLGNV PWSVGESFAQ SPWDFMMKNK
AEHITVLLSG PQEGCLSSVT YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL
ALCLKHRQMA AGFSCEIVRA EVDSGFSKKQ LLDLFISNAC LIPVKQSPVK KKIIIILENL
EKSSLSELLR DFLAPLENRS TESPCTFQKG NGMSECYYFH ENCFLMGTIA KACLQGSDLL
VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFRGQVPPP CDPVCKIVDW ALSVWRQLNS
CLARLGTPEA LLGPKYFLSC PVVPGHAQVT VKWMSKLWNG VITPRVQEAI LSRASVKRQP
GFGQTTAKRH PSQGQQAVVK AALSILLNKA VLHGCPLPRA ELEQHTADFK GGSFPLSIVS
SFNSCSKKKG ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGIKNKTLS QLNCNRNASL
SKQKSVENDV SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA DSRDDLRMFN
SPGNNPVFSA TVNNLRMPVS QKEVCPLSSH QTTECSNSKS KTELGVSRVK SFLPVPRSKV
TQCSQNTKSS SSSSNTRQIE INNNSKEENW NLHKNEHLEK ANK
