ID   32C7_ANCSP              Reviewed;          37 AA.
AC   P84027;
DT   30-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=U1-ctenitoxin-Asp1a;
DE            Short=U1-CNTX-Asp1a;
DE   AltName: Full=Neurotoxin ANC32C7;
DE   Flags: Fragment;
OS   Ancylometes sp. (South American fishing spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Ancylometes;
OC   unclassified Ancylometes.
OX   NCBI_TaxID=280265;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RA   Richardson M., Pimenta A.M.C., Bemquerer M.P., Santoro M.M.,
RA   Figueiredo S.G., Cordeiro M.N.;
RT   "Protein ANC32C7 from venom of South American fishing spider (Ancylometes
RT   spp.) has sequence similarities to omega agatoxins and other neurotoxins.";
RL   Submitted (JUN-2004) to UniProtKB.
CC   -!- FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium
CC       channels (Cav). They block neuromuscular transmission presynaptically
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=8825.5; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type
CC       II/III omega-agtx) subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P84027; -.
DR   ArachnoServer; AS000015; U1-ctenitoxin-Asp1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR005853; Omega-agatoxin_II/III_CS.
DR   InterPro; IPR013605; Toxin_34.
DR   Pfam; PF08396; Toxin_34; 1.
DR   PROSITE; PS60023; OMEGA_AGA_II_III; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing;
KW   Ion channel impairing toxin; Neurotoxin; Presynaptic neurotoxin; Secreted;
KW   Toxin; Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..>37
FT                   /note="U1-ctenitoxin-Asp1a"
FT                   /id="PRO_0000087611"
FT   NON_TER         37
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   37 AA;  4066 MW;  1EAE19832B32148C CRC64;
     SDNEFPSGCI EFGKECDLDK GNCQCCRRNG YCSCAVN