位置:首页 > 蛋白库 > CTU2A_XENLA
CTU2A_XENLA
ID   CTU2A_XENLA             Reviewed;         512 AA.
AC   Q08B12; Q4V7Y1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Cytoplasmic tRNA 2-thiolation protein 2-A {ECO:0000255|HAMAP-Rule:MF_03054};
GN   Name=ctu2-a; Synonyms=ncs2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA
CC       wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by
CC       forming a heterodimer with ctu1/atpbd3 that ligates sulfur from
CC       thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.
CC       {ECO:0000255|HAMAP-Rule:MF_03054}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03054}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03054}.
CC   -!- SIMILARITY: Belongs to the CTU2/NCS2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03054}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH97664.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097664; AAH97664.1; ALT_INIT; mRNA.
DR   EMBL; BC124921; AAI24922.1; -; mRNA.
DR   RefSeq; NP_001167511.1; NM_001174040.1.
DR   AlphaFoldDB; Q08B12; -.
DR   BioGRID; 1079194; 1.
DR   IntAct; Q08B12; 1.
DR   DNASU; 100381163; -.
DR   GeneID; 100381163; -.
DR   KEGG; xla:100381163; -.
DR   CTD; 348180; -.
DR   Xenbase; XB-GENE-6466467; ctu2.L.
DR   OrthoDB; 1442062at2759; -.
DR   UniPathway; UPA00988; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 100381163; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0032447; P:protein urmylation; IEA:UniProtKB-UniRule.
DR   GO; GO:0034227; P:tRNA thio-modification; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; ISS:UniProtKB.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_03054; CTU2; 1.
DR   InterPro; IPR019407; CTU2.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR20882; PTHR20882; 1.
DR   Pfam; PF10288; CTU2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; tRNA processing.
FT   CHAIN           1..512
FT                   /note="Cytoplasmic tRNA 2-thiolation protein 2-A"
FT                   /id="PRO_0000289180"
FT   CONFLICT        456
FT                   /note="P -> H (in Ref. 1; AAH97664)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   512 AA;  57231 MW;  42B1184BD32CE7D3 CRC64;
     MCEEGETYCP EVKDAKQGKS LGKICMKCKE SSAALLIRAG DAFCKSCFKE YFVHKFRATL
     GKNRVIYPGE KVLLAYSGGP SSSAMVRQVQ EGLSRDAPKK LRFVPGILFI DEGTACGMSW
     EERQQILSEI CSVLQQTKIP FHIVSLEQVF SLPGSVLQRG APEQRPNYKE EVDRFLVQER
     EQGDAGCSEM LERLEVTDSD SPGSSDKMYQ STCSHPPDMH TQKLKQLFAS AKTLTAKQQL
     LHTLRSHLIL HIARTCGYSK VMTGESCTRL SIRLLSNVSL GRGAFLPLDT GFCDSRYGDV
     DIIRPMREYS SKEIAYYNRF FNVSPIFIPA LDTKASENSS IQHLTEVFVN RLQADFPSTV
     STLYRTSEKL NVSKIDADQE TCAKDRCLLC LSPLDTQAGK ASAFSATQLS HHLSQKIPMK
     SNDLANNSDK SCCQGGQGCK EAGYGDTCQS RALQTPSFVH MLCYSCRLTV KDMQSLDVLP
     QYVLHEAEHR CHRTEMRKEI QEFLLDEDDG DS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024