ID   CTXB_CERCA              Reviewed;          29 AA.
AC   P36191;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ceratotoxin-B;
GN   Name=CTXB;
OS   Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC   Tephritidae; Ceratitis; Ceratitis.
OX   NCBI_TaxID=7213;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Female accessory gland;
RX   PubMed=8353519; DOI=10.1016/0965-1748(93)90032-n;
RA   Marchini D., Giordano P.C., Amons R., Bernini L.F., Dallai R.;
RT   "Purification and primary structure of ceratotoxin A and B, two
RT   antibacterial peptides from the female reproductive accessory glands of the
RT   medfly Ceratitis capitata (Insecta: Diptera).";
RL   Insect Biochem. Mol. Biol. 23:591-598(1993).
CC   -!- FUNCTION: Female-specific peptides with potent activity against Gram-
CC       positive and Gram-negative bacteria. They have as well hemolytic
CC       activity.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Temperature dependence:
CC         Thermostable. Still active at 100 degrees Celsius.;
CC   -!- SUBUNIT: Homomer of four to six subunits.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PIR; B61613; B61613.
DR   AlphaFoldDB; P36191; -.
DR   TCDB; 1.C.52.2.2; the dermaseptin (dermaseptin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Immunity; Innate immunity; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Ceratotoxin-B"
FT                   /id="PRO_0000043593"
SQ   SEQUENCE   29 AA;  2861 MW;  EE57F4EECB2DA6B0 CRC64;
     SIGSAFKKAL PVAKKIGKAA LPIAKAALP