ID   CTXN1_HUMAN             Reviewed;          82 AA.
AC   P60606;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Cortexin-1;
GN   Name=CTXN1; Synonyms=CTXN;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May mediate extracellular or intracellular signaling of
CC       cortical neurons during forebrain development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cortexin family. {ECO:0000305}.
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DR   EMBL; BC062702; AAH62702.1; -; mRNA.
DR   CCDS; CCDS12191.1; -.
DR   RefSeq; NP_996664.1; NM_206833.3.
DR   AlphaFoldDB; P60606; -.
DR   SMR; P60606; -.
DR   BioGRID; 135653; 33.
DR   STRING; 9606.ENSP00000313226; -.
DR   iPTMnet; P60606; -.
DR   PhosphoSitePlus; P60606; -.
DR   SwissPalm; P60606; -.
DR   BioMuta; CTXN1; -.
DR   DMDM; 45476804; -.
DR   MassIVE; P60606; -.
DR   PaxDb; P60606; -.
DR   PeptideAtlas; P60606; -.
DR   PRIDE; P60606; -.
DR   ProteomicsDB; 57219; -.
DR   Antibodypedia; 2649; 22 antibodies from 8 providers.
DR   DNASU; 404217; -.
DR   Ensembl; ENST00000318978.6; ENSP00000313226.3; ENSG00000178531.6.
DR   GeneID; 404217; -.
DR   KEGG; hsa:404217; -.
DR   MANE-Select; ENST00000318978.6; ENSP00000313226.3; NM_206833.4; NP_996664.1.
DR   UCSC; uc002miy.5; human.
DR   CTD; 404217; -.
DR   GeneCards; CTXN1; -.
DR   HGNC; HGNC:31108; CTXN1.
DR   HPA; ENSG00000178531; Tissue enhanced (brain, endometrium).
DR   MIM; 600135; gene.
DR   neXtProt; NX_P60606; -.
DR   OpenTargets; ENSG00000178531; -.
DR   PharmGKB; PA134944051; -.
DR   VEuPathDB; HostDB:ENSG00000178531; -.
DR   eggNOG; ENOG502S3S8; Eukaryota.
DR   GeneTree; ENSGT00940000154412; -.
DR   HOGENOM; CLU_193122_0_0_1; -.
DR   InParanoid; P60606; -.
DR   OMA; ILMVRCF; -.
DR   PhylomeDB; P60606; -.
DR   TreeFam; TF333403; -.
DR   PathwayCommons; P60606; -.
DR   SignaLink; P60606; -.
DR   BioGRID-ORCS; 404217; 31 hits in 1074 CRISPR screens.
DR   ChiTaRS; CTXN1; human.
DR   GenomeRNAi; 404217; -.
DR   Pharos; P60606; Tdark.
DR   PRO; PR:P60606; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P60606; protein.
DR   Bgee; ENSG00000178531; Expressed in nucleus accumbens and 97 other tissues.
DR   Genevisible; P60606; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR020066; Cortexin.
DR   PANTHER; PTHR16736; PTHR16736; 1.
DR   Pfam; PF11057; Cortexin; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="Cortexin-1"
FT                   /id="PRO_0000079500"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   82 AA;  9045 MW;  BEEA6DBEDA10F0D3 CRC64;
     MSATWTLSPE PLPPSTGPPV GAGLDAEQRT VFAFVLCLLV VLVLLMVRCV RILLDPYSRM
     PASSWTDHKE ALERGQFDYA LV