ID   CTXN2_HUMAN             Reviewed;          81 AA.
AC   P0C2S0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Cortexin-2;
GN   Name=CTXN2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cortexin family. {ECO:0000305}.
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DR   EMBL; BX537772; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC066612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45254.1; -.
DR   RefSeq; NP_001139140.1; NM_001145668.1.
DR   RefSeq; XP_005254435.1; XM_005254378.3.
DR   RefSeq; XP_006720567.1; XM_006720504.2.
DR   RefSeq; XP_011519855.1; XM_011521553.1.
DR   RefSeq; XP_016877667.1; XM_017022178.1.
DR   AlphaFoldDB; P0C2S0; -.
DR   SMR; P0C2S0; -.
DR   STRING; 9606.ENSP00000406145; -.
DR   BioMuta; CTXN2; -.
DR   DMDM; 145558892; -.
DR   PaxDb; P0C2S0; -.
DR   PRIDE; P0C2S0; -.
DR   ProteomicsDB; 52304; -.
DR   Antibodypedia; 65141; 5 antibodies from 5 providers.
DR   DNASU; 399697; -.
DR   Ensembl; ENST00000417307.3; ENSP00000406145.2; ENSG00000233932.6.
DR   Ensembl; ENST00000644354.1; ENSP00000495988.1; ENSG00000233932.6.
DR   Ensembl; ENST00000645050.1; ENSP00000495979.1; ENSG00000233932.6.
DR   Ensembl; ENST00000647363.1; ENSP00000493942.1; ENSG00000233932.6.
DR   GeneID; 399697; -.
DR   KEGG; hsa:399697; -.
DR   MANE-Select; ENST00000417307.3; ENSP00000406145.2; NM_001145668.2; NP_001139140.1.
DR   UCSC; uc001zwm.2; human.
DR   CTD; 399697; -.
DR   DisGeNET; 399697; -.
DR   GeneCards; CTXN2; -.
DR   HGNC; HGNC:31109; CTXN2.
DR   HPA; ENSG00000233932; Tissue enhanced (brain, choroid plexus, pituitary gland, retina).
DR   neXtProt; NX_P0C2S0; -.
DR   OpenTargets; ENSG00000233932; -.
DR   PharmGKB; PA134951739; -.
DR   VEuPathDB; HostDB:ENSG00000233932; -.
DR   eggNOG; ENOG502S3V3; Eukaryota.
DR   GeneTree; ENSGT00940000154412; -.
DR   HOGENOM; CLU_193122_0_0_1; -.
DR   InParanoid; P0C2S0; -.
DR   OMA; ASMSVNK; -.
DR   OrthoDB; 1622786at2759; -.
DR   PhylomeDB; P0C2S0; -.
DR   TreeFam; TF333403; -.
DR   PathwayCommons; P0C2S0; -.
DR   BioGRID-ORCS; 399697; 2 hits in 1045 CRISPR screens.
DR   GenomeRNAi; 399697; -.
DR   Pharos; P0C2S0; Tdark.
DR   PRO; PR:P0C2S0; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; P0C2S0; protein.
DR   Bgee; ENSG00000233932; Expressed in prefrontal cortex and 36 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR020066; Cortexin.
DR   PANTHER; PTHR16736; PTHR16736; 1.
DR   Pfam; PF11057; Cortexin; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..81
FT                   /note="Cortexin-2"
FT                   /id="PRO_0000284616"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   81 AA;  8980 MW;  52A01611040EC94D CRC64;
     MSSTYCGNSS AKMSVNEVSA FSLTLEQKTG FAFVGILCIF LGLLIIRCFK ILLDPYSSMP
     SSTWEDEVEE FDKGTFEYAL A