CTXN3_HUMAN
ID CTXN3_HUMAN Reviewed; 81 AA.
AC Q4LDR2; B2RV32; D3DQ82;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Cortexin-3;
DE AltName: Full=Kidney and brain-expressed protein;
GN Name=CTXN3; Synonyms=KABE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RA Wang H., Chang J., Ma X., Zhang Y., Ma F.;
RT "In silico-initiated cloning and molecular characterization of KABE, a
RT novel gene specifically expressed in kidney, brain and well conserved in
RT vertebrate.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-17.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q4LDR2; Q86Y34: ADGRG3; NbExp=3; IntAct=EBI-12019274, EBI-17979264;
CC Q4LDR2; Q13520: AQP6; NbExp=3; IntAct=EBI-12019274, EBI-13059134;
CC Q4LDR2; O43315: AQP9; NbExp=3; IntAct=EBI-12019274, EBI-17444777;
CC Q4LDR2; P54709: ATP1B3; NbExp=3; IntAct=EBI-12019274, EBI-1054481;
CC Q4LDR2; Q13323: BIK; NbExp=3; IntAct=EBI-12019274, EBI-700794;
CC Q4LDR2; Q7KYR7-4: BTN2A1; NbExp=3; IntAct=EBI-12019274, EBI-17841208;
CC Q4LDR2; Q496F6: CD300E; NbExp=3; IntAct=EBI-12019274, EBI-18010148;
CC Q4LDR2; P19397: CD53; NbExp=3; IntAct=EBI-12019274, EBI-6657396;
CC Q4LDR2; P11912: CD79A; NbExp=3; IntAct=EBI-12019274, EBI-7797864;
CC Q4LDR2; Q9HA82: CERS4; NbExp=3; IntAct=EBI-12019274, EBI-2622997;
CC Q4LDR2; O95500: CLDN14; NbExp=3; IntAct=EBI-12019274, EBI-11742599;
CC Q4LDR2; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-12019274, EBI-11977093;
CC Q4LDR2; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-12019274, EBI-11989440;
CC Q4LDR2; P58418: CLRN1; NbExp=3; IntAct=EBI-12019274, EBI-17274839;
CC Q4LDR2; O75208: COQ9; NbExp=3; IntAct=EBI-12019274, EBI-724524;
CC Q4LDR2; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12019274, EBI-18013275;
CC Q4LDR2; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12019274, EBI-6942903;
CC Q4LDR2; P16410: CTLA4; NbExp=3; IntAct=EBI-12019274, EBI-1030991;
CC Q4LDR2; Q92838: EDA; NbExp=3; IntAct=EBI-12019274, EBI-529425;
CC Q4LDR2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12019274, EBI-781551;
CC Q4LDR2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12019274, EBI-18304435;
CC Q4LDR2; O14843: FFAR3; NbExp=3; IntAct=EBI-12019274, EBI-17762181;
CC Q4LDR2; Q11130: FUT7; NbExp=3; IntAct=EBI-12019274, EBI-12817667;
CC Q4LDR2; P48165: GJA8; NbExp=3; IntAct=EBI-12019274, EBI-17458373;
CC Q4LDR2; P08034: GJB1; NbExp=3; IntAct=EBI-12019274, EBI-17565645;
CC Q4LDR2; O95377: GJB5; NbExp=3; IntAct=EBI-12019274, EBI-3909454;
CC Q4LDR2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12019274, EBI-13345167;
CC Q4LDR2; O15529: GPR42; NbExp=3; IntAct=EBI-12019274, EBI-18076404;
CC Q4LDR2; Q9BZJ8: GPR61; NbExp=3; IntAct=EBI-12019274, EBI-12808020;
CC Q4LDR2; Q8IU57: IFNLR1; NbExp=3; IntAct=EBI-12019274, EBI-373215;
CC Q4LDR2; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-12019274, EBI-749265;
CC Q4LDR2; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-12019274, EBI-17272405;
CC Q4LDR2; P26715: KLRC1; NbExp=3; IntAct=EBI-12019274, EBI-9018187;
CC Q4LDR2; Q86VI4: LAPTM4B; NbExp=3; IntAct=EBI-12019274, EBI-3267258;
CC Q4LDR2; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-12019274, EBI-10173166;
CC Q4LDR2; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12019274, EBI-2820517;
CC Q4LDR2; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-12019274, EBI-10264855;
CC Q4LDR2; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12019274, EBI-11956541;
CC Q4LDR2; Q99735: MGST2; NbExp=5; IntAct=EBI-12019274, EBI-11324706;
CC Q4LDR2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-12019274, EBI-3923617;
CC Q4LDR2; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-12019274, EBI-10247000;
CC Q4LDR2; P41143: OPRD1; NbExp=3; IntAct=EBI-12019274, EBI-2624456;
CC Q4LDR2; P35372-10: OPRM1; NbExp=3; IntAct=EBI-12019274, EBI-12807478;
CC Q4LDR2; Q9H813: PACC1; NbExp=3; IntAct=EBI-12019274, EBI-4319734;
CC Q4LDR2; Q8NEB5: PLPP5; NbExp=3; IntAct=EBI-12019274, EBI-2803478;
CC Q4LDR2; P15151: PVR; NbExp=3; IntAct=EBI-12019274, EBI-3919694;
CC Q4LDR2; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12019274, EBI-17247926;
CC Q4LDR2; Q12908: SLC10A2; NbExp=3; IntAct=EBI-12019274, EBI-18114847;
CC Q4LDR2; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-12019274, EBI-17498703;
CC Q4LDR2; P27105: STOM; NbExp=3; IntAct=EBI-12019274, EBI-1211440;
CC Q4LDR2; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-12019274, EBI-12947623;
CC Q4LDR2; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-12019274, EBI-6448756;
CC Q4LDR2; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-12019274, EBI-2821497;
CC Q4LDR2; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-12019274, EBI-17684533;
CC Q4LDR2; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-12019274, EBI-11724423;
CC Q4LDR2; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12019274, EBI-12345267;
CC Q4LDR2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-12019274, EBI-6447886;
CC Q4LDR2; O95859: TSPAN12; NbExp=3; IntAct=EBI-12019274, EBI-2466403;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cortexin family. {ECO:0000305}.
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DR EMBL; AB219764; BAE06183.1; -; mRNA.
DR EMBL; AB219832; BAE06184.1; -; mRNA.
DR EMBL; CH471062; EAW62400.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62401.1; -; Genomic_DNA.
DR EMBL; BC147012; AAI47013.1; -; mRNA.
DR CCDS; CCDS34221.1; -.
DR RefSeq; NP_001041717.1; NM_001048252.2.
DR RefSeq; NP_001120857.1; NM_001127385.1.
DR AlphaFoldDB; Q4LDR2; -.
DR SMR; Q4LDR2; -.
DR BioGRID; 534792; 59.
DR IntAct; Q4LDR2; 58.
DR STRING; 9606.ENSP00000368758; -.
DR iPTMnet; Q4LDR2; -.
DR PhosphoSitePlus; Q4LDR2; -.
DR BioMuta; CTXN3; -.
DR DMDM; 121944345; -.
DR PaxDb; Q4LDR2; -.
DR PeptideAtlas; Q4LDR2; -.
DR PRIDE; Q4LDR2; -.
DR DNASU; 613212; -.
DR Ensembl; ENST00000379445.8; ENSP00000368758.3; ENSG00000205279.9.
DR Ensembl; ENST00000395322.3; ENSP00000378732.3; ENSG00000205279.9.
DR Ensembl; ENST00000620385.1; ENSP00000482081.1; ENSG00000205279.9.
DR GeneID; 613212; -.
DR KEGG; hsa:613212; -.
DR MANE-Select; ENST00000379445.8; ENSP00000368758.3; NM_001048252.3; NP_001041717.1.
DR UCSC; uc003kul.5; human.
DR CTD; 613212; -.
DR DisGeNET; 613212; -.
DR GeneCards; CTXN3; -.
DR HGNC; HGNC:31110; CTXN3.
DR HPA; ENSG00000205279; Tissue enriched (kidney).
DR MIM; 618746; gene.
DR neXtProt; NX_Q4LDR2; -.
DR OpenTargets; ENSG00000205279; -.
DR PharmGKB; PA134959223; -.
DR VEuPathDB; HostDB:ENSG00000205279; -.
DR eggNOG; ENOG502S3V3; Eukaryota.
DR GeneTree; ENSGT00940000154412; -.
DR HOGENOM; CLU_193122_0_0_1; -.
DR InParanoid; Q4LDR2; -.
DR OMA; RKLWDYS; -.
DR OrthoDB; 1640476at2759; -.
DR PhylomeDB; Q4LDR2; -.
DR TreeFam; TF333403; -.
DR PathwayCommons; Q4LDR2; -.
DR SignaLink; Q4LDR2; -.
DR BioGRID-ORCS; 613212; 5 hits in 1061 CRISPR screens.
DR GenomeRNAi; 613212; -.
DR Pharos; Q4LDR2; Tbio.
DR PRO; PR:Q4LDR2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q4LDR2; protein.
DR Bgee; ENSG00000205279; Expressed in kidney epithelium and 75 other tissues.
DR Genevisible; Q4LDR2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR020066; Cortexin.
DR PANTHER; PTHR16736; PTHR16736; 1.
DR Pfam; PF11057; Cortexin; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..81
FT /note="Cortexin-3"
FT /id="PRO_0000284513"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 17
FT /note="E -> V (in dbSNP:rs248709)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_031763"
FT VARIANT 23
FT /note="M -> I (in dbSNP:rs2280170)"
FT /id="VAR_053885"
SQ SEQUENCE 81 AA; 8933 MW; 490CDAAC2ABE2A0B CRC64;
MDGGQPIPSS LVPLGNESAD SSMSLEQKMT FVFVILLFIF LGILIVRCFR ILLDPYRSMP
TSTWADGLEG LEKGQFDHAL A
