CU058_HUMAN
ID CU058_HUMAN Reviewed; 322 AA.
AC P58505; B3KPI1; Q8N7N9;
DT 19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized protein C21orf58;
GN Name=C21orf58;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 39-322 (ISOFORMS 1 AND 2).
RX PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT chromosome 21 transcription map.";
RL Genomics 78:46-54(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P58505-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P58505-2; Sequence=VSP_003827, VSP_003828;
CC Name=3;
CC IsoId=P58505-3; Sequence=VSP_057984;
CC -!- TISSUE SPECIFICITY: Expressed in skin and fetal lung.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK72408.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAK72409.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK098098; BAC05232.1; -; mRNA.
DR EMBL; AK056387; BAG51693.1; -; mRNA.
DR EMBL; AP000471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY039243; AAK72408.1; ALT_INIT; mRNA.
DR EMBL; AY039244; AAK72409.1; ALT_INIT; mRNA.
DR CCDS; CCDS13735.1; -. [P58505-1]
DR CCDS; CCDS68229.1; -. [P58505-3]
DR RefSeq; NP_001273391.1; NM_001286462.1. [P58505-3]
DR RefSeq; NP_001273392.1; NM_001286463.1. [P58505-3]
DR RefSeq; NP_001273405.1; NM_001286476.1. [P58505-3]
DR RefSeq; NP_001273406.1; NM_001286477.1. [P58505-3]
DR RefSeq; NP_478060.2; NM_058180.4. [P58505-1]
DR RefSeq; XP_005261205.1; XM_005261148.4. [P58505-1]
DR RefSeq; XP_006724081.1; XM_006724018.3. [P58505-2]
DR RefSeq; XP_011527921.1; XM_011529619.2. [P58505-1]
DR RefSeq; XP_011527922.1; XM_011529620.2. [P58505-1]
DR RefSeq; XP_011527927.1; XM_011529625.2.
DR RefSeq; XP_011527928.1; XM_011529626.2.
DR RefSeq; XP_011527929.1; XM_011529627.2.
DR RefSeq; XP_016883877.1; XM_017028388.1.
DR RefSeq; XP_016883878.1; XM_017028389.1.
DR RefSeq; XP_016883879.1; XM_017028390.1.
DR RefSeq; XP_016883880.1; XM_017028391.1.
DR RefSeq; XP_016883881.1; XM_017028392.1. [P58505-3]
DR RefSeq; XP_016883882.1; XM_017028393.1. [P58505-3]
DR AlphaFoldDB; P58505; -.
DR SMR; P58505; -.
DR BioGRID; 119868; 18.
DR IntAct; P58505; 3.
DR MINT; P58505; -.
DR STRING; 9606.ENSP00000291691; -.
DR iPTMnet; P58505; -.
DR PhosphoSitePlus; P58505; -.
DR BioMuta; C21orf58; -.
DR DMDM; 215274005; -.
DR EPD; P58505; -.
DR MassIVE; P58505; -.
DR PaxDb; P58505; -.
DR PeptideAtlas; P58505; -.
DR PRIDE; P58505; -.
DR ProteomicsDB; 57080; -. [P58505-1]
DR ProteomicsDB; 57081; -. [P58505-2]
DR ProteomicsDB; 72310; -.
DR Antibodypedia; 24660; 73 antibodies from 18 providers.
DR DNASU; 54058; -.
DR Ensembl; ENST00000291691.12; ENSP00000291691.8; ENSG00000160298.18. [P58505-1]
DR Ensembl; ENST00000397679.5; ENSP00000380796.1; ENSG00000160298.18. [P58505-3]
DR Ensembl; ENST00000397680.5; ENSP00000380797.1; ENSG00000160298.18. [P58505-3]
DR Ensembl; ENST00000397682.7; ENSP00000380798.3; ENSG00000160298.18. [P58505-3]
DR Ensembl; ENST00000397683.5; ENSP00000380799.1; ENSG00000160298.18. [P58505-3]
DR GeneID; 54058; -.
DR KEGG; hsa:54058; -.
DR MANE-Select; ENST00000291691.12; ENSP00000291691.8; NM_058180.5; NP_478060.2.
DR UCSC; uc002zja.3; human.
DR UCSC; uc002zjf.5; human. [P58505-1]
DR CTD; 54058; -.
DR DisGeNET; 54058; -.
DR GeneCards; C21orf58; -.
DR HGNC; HGNC:1300; C21orf58.
DR HPA; ENSG00000160298; Tissue enhanced (fallopian tube, pituitary gland).
DR neXtProt; NX_P58505; -.
DR OpenTargets; ENSG00000160298; -.
DR PharmGKB; PA25853; -.
DR VEuPathDB; HostDB:ENSG00000160298; -.
DR eggNOG; ENOG502QV5Q; Eukaryota.
DR GeneTree; ENSGT00390000011514; -.
DR InParanoid; P58505; -.
DR OMA; QAWSERA; -.
DR OrthoDB; 993450at2759; -.
DR PhylomeDB; P58505; -.
DR TreeFam; TF336319; -.
DR PathwayCommons; P58505; -.
DR SignaLink; P58505; -.
DR BioGRID-ORCS; 54058; 14 hits in 1052 CRISPR screens.
DR ChiTaRS; C21orf58; human.
DR GenomeRNAi; 54058; -.
DR Pharos; P58505; Tdark.
DR PRO; PR:P58505; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P58505; protein.
DR Bgee; ENSG00000160298; Expressed in right uterine tube and 102 other tissues.
DR ExpressionAtlas; P58505; baseline and differential.
DR Genevisible; P58505; HS.
DR InterPro; IPR027904; DUF4587.
DR InterPro; IPR038915; PRR29-like.
DR PANTHER; PTHR28604; PTHR28604; 1.
DR Pfam; PF15248; DUF4587; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..322
FT /note="Uncharacterized protein C21orf58"
FT /id="PRO_0000079521"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..148
FT /note="MARSRLPATSLRKPWKLDRQKLPSPDSGHSLLCGWSPGGKARPAGNTGAWAP
FT AEQFFPASNRTREGGGLWPPLPLQSSPAAPTMLDSSAAEQVTRLTLKLLGQKLEQERQN
FT VEGGPEGLHLEPGNEDRPDDALQTALKRRRDLLQRLR -> MAILPGEAPVPGPGWPEP
FT DAGGASVALGLPVPVCSSSASALQ (in isoform 3)"
FT /id="VSP_057984"
FT VAR_SEQ 273..277
FT /note="PPHVP -> RFFHS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11707072"
FT /id="VSP_003827"
FT VAR_SEQ 278..322
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11707072"
FT /id="VSP_003828"
FT CONFLICT 111
FT /note="N -> D (in Ref. 1; BAG51693)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 322 AA; 35003 MW; 06DB0577FFAD57D6 CRC64;
MARSRLPATS LRKPWKLDRQ KLPSPDSGHS LLCGWSPGGK ARPAGNTGAW APAEQFFPAS
NRTREGGGLW PPLPLQSSPA APTMLDSSAA EQVTRLTLKL LGQKLEQERQ NVEGGPEGLH
LEPGNEDRPD DALQTALKRR RDLLQRLREQ HLLDELSRAQ AWSGPSRGAL GSALPPELPP
TGILPTASPS PLAPDPPRII LPTVPQPPAT IIQQLPQQPL IAQIPPPQAF PTQRSGSIKE
DMVELLLLQN AQVHQLVLQN WMLKALPPAL QDPPHVPPRV PRAARPRLPA VHHHHHHHHA
VWPPGAATVL QPAPSLWTPG PP
