CU062_HUMAN
ID CU062_HUMAN Reviewed; 219 AA.
AC Q9NYP8; A8K4L8;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized protein C21orf62;
DE AltName: Full=B37;
DE Flags: Precursor;
GN Name=C21orf62; Synonyms=C21orf120;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10773462; DOI=10.1016/s0378-1119(00)00089-5;
RA Slavov D., Hattori M., Sakaki Y., Rosenthal A., Shimizu N., Minoshima S.,
RA Kudoh J., Yaspo M.-L., Ramser J., Reinhardt R., Reimer C., Clancy K.,
RA Rynditch A., Gardiner K.;
RT "Criteria for gene identification and features of genome organization:
RT analysis of 6.5 Mb of DNA sequence from human chromosome 21.";
RL Gene 247:215-232(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF72946.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF231922; AAF72946.1; ALT_FRAME; mRNA.
DR EMBL; AK290983; BAF83672.1; -; mRNA.
DR EMBL; AP000280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42919.2; -.
DR RefSeq; NP_001155967.2; NM_001162495.2.
DR RefSeq; NP_001155968.2; NM_001162496.2.
DR RefSeq; NP_062542.5; NM_019596.5.
DR AlphaFoldDB; Q9NYP8; -.
DR STRING; 9606.ENSP00000444950; -.
DR GlyGen; Q9NYP8; 3 sites.
DR iPTMnet; Q9NYP8; -.
DR PhosphoSitePlus; Q9NYP8; -.
DR BioMuta; C21orf62; -.
DR DMDM; 281371552; -.
DR PaxDb; Q9NYP8; -.
DR PRIDE; Q9NYP8; -.
DR Antibodypedia; 4996; 105 antibodies from 17 providers.
DR DNASU; 56245; -.
DR Ensembl; ENST00000479548.2; ENSP00000418653.1; ENSG00000205929.11.
DR Ensembl; ENST00000487113.1; ENSP00000418511.1; ENSG00000205929.11.
DR Ensembl; ENST00000490358.5; ENSP00000418830.1; ENSG00000205929.11.
DR Ensembl; ENST00000571812.1; ENSP00000461558.1; ENSG00000262938.6.
DR Ensembl; ENST00000576061.1; ENSP00000460629.1; ENSG00000262938.6.
DR Ensembl; ENST00000576372.5; ENSP00000461359.1; ENSG00000262938.6.
DR GeneID; 56245; -.
DR KEGG; hsa:56245; -.
DR MANE-Select; ENST00000479548.2; ENSP00000418653.1; NM_001162495.3; NP_001155967.2.
DR UCSC; uc010glz.4; human.
DR CTD; 56245; -.
DR DisGeNET; 56245; -.
DR GeneCards; C21orf62; -.
DR HGNC; HGNC:1305; C21orf62.
DR HPA; ENSG00000205929; Tissue enhanced (choroid plexus, epididymis, ovary).
DR neXtProt; NX_Q9NYP8; -.
DR OpenTargets; ENSG00000205929; -.
DR PharmGKB; PA25857; -.
DR VEuPathDB; HostDB:ENSG00000205929; -.
DR eggNOG; ENOG502S2I2; Eukaryota.
DR GeneTree; ENSGT00390000016499; -.
DR HOGENOM; CLU_079917_0_0_1; -.
DR InParanoid; Q9NYP8; -.
DR OrthoDB; 1309180at2759; -.
DR PhylomeDB; Q9NYP8; -.
DR TreeFam; TF336022; -.
DR PathwayCommons; Q9NYP8; -.
DR BioGRID-ORCS; 56245; 8 hits in 1059 CRISPR screens.
DR ChiTaRS; C21orf62; human.
DR GenomeRNAi; 56245; -.
DR Pharos; Q9NYP8; Tdark.
DR PRO; PR:Q9NYP8; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q9NYP8; protein.
DR Bgee; ENSG00000205929; Expressed in ovary and 84 other tissues.
DR ExpressionAtlas; Q9NYP8; baseline and differential.
DR Genevisible; Q9NYP8; HS.
DR InterPro; IPR029250; DUF4571.
DR PANTHER; PTHR35658; PTHR35658; 1.
DR Pfam; PF15137; DUF4571; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..219
FT /note="Uncharacterized protein C21orf62"
FT /id="PRO_0000079524"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 24852 MW; 44D0B404ECDD88B1 CRC64;
MAPPSRHCLL LISTLGVFAL NCFTKGQKNS TLIFTRENTI RNCSCSADIR DCDYSLANLM
CNCKTVLPLA VERTSYNGHL TIWFTDTSAL GHLLNFTLVQ DLKLSLCSTN TLPTEYLAIC
GLKRLRINME AKHPFPEQSL LIHSGGDSDS REKPMWLHKG WQPCMYISFL DMALFNRDSA
LKSYSIENVT SIANNFPDFS YFRTFPMPSN KSYVVTFIY