ID   CU14_MANSE              Reviewed;         125 AA.
AC   P13229;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Larval cuticle protein LCP-14;
DE   Flags: Precursor;
GN   Name=LCP-14;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Dorsal-abdominal integument;
RX   PubMed=2462055; DOI=10.1016/0022-2836(88)90009-5;
RA   Rebers J.E., Riddiford L.M.;
RT   "Structure and expression of a Manduca sexta larval cuticle gene homologous
RT   to Drosophila cuticle genes.";
RL   J. Mol. Biol. 203:411-423(1988).
CC   -!- FUNCTION: Component of the cuticle of the larva of tobacco hornworm.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout both the four and the fifth
CC       larval instars.
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DR   EMBL; X13279; CAA31643.1; -; mRNA.
DR   EMBL; X13277; CAA31641.1; -; Genomic_DNA.
DR   EMBL; M18546; AAA29318.1; -; mRNA.
DR   EMBL; M26395; AAA29319.1; -; Genomic_DNA.
DR   EMBL; M26394; AAA29319.1; JOINED; Genomic_DNA.
DR   PIR; S01374; S01374.
DR   AlphaFoldDB; P13229; -.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   2: Evidence at transcript level;
KW   Cuticle; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250"
FT   CHAIN           17..125
FT                   /note="Larval cuticle protein LCP-14"
FT                   /id="PRO_0000006407"
FT   DOMAIN          33..102
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   VARIANT         105
FT                   /note="V -> A"
SQ   SEQUENCE   125 AA;  13346 MW;  69278D1A257EDA30 CRC64;
     MKSFIVALCV VGCVLANDPE AVVVRNDYVQ NPEGSYNYAF ESNNGISGQA EGKFKVFDKD
     SAAVVVAGSS QYKGSDGKVY SLTYVADENG YQPQADFLPT PPPTVAIPEY IARAVAYNLA
     HSAKV