ID   CU168_IXORI             Reviewed;         161 AA.
AC   P84252;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Cuticle protein 16.8;
DE   AltName: Full=Ir-ACP16.8;
OS   Ixodes ricinus (Common tick) (Acarus ricinus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=34613;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND PYROGLUTAMATE FORMATION
RP   AT GLN-1.
RC   TISSUE=Cuticle;
RX   PubMed=16102423; DOI=10.1016/j.ibmb.2005.05.009;
RA   Andersen S.O., Roepstorff P.;
RT   "The extensible alloscutal cuticle of the tick, Ixodes ricinus.";
RL   Insect Biochem. Mol. Biol. 35:1181-1188(2005).
CC   -!- FUNCTION: Component of the cuticle of the tick. Binds chitin.
CC       {ECO:0000269|PubMed:16102423}.
CC   -!- MASS SPECTROMETRY: Mass=16812.2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16102423};
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DR   AlphaFoldDB; P84252; -.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.10; -; 1.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   1: Evidence at protein level;
KW   Chitin-binding; Cuticle; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid.
FT   CHAIN           1..161
FT                   /note="Cuticle protein 16.8"
FT                   /id="PRO_0000196127"
FT   DOMAIN          8..74
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:16102423"
SQ   SEQUENCE   161 AA;  16829 MW;  F6DE25EC513084AA CRC64;
     QSEPAGPPQP YTFSYDNTDE YGTRIAQEET GDENNNKVGS YSYTDPNGIS RTVKYVADAE
     GFRVTVETNE PGTKTSNPAD AQIVSNAATD SYSPSPASSP AKPPSLAVNA APITIHAVHA
     SPVVHAIHAA PVSYATAHHV TPVIALSHAP LTYTLGRAKS A