ID   CU16_MANSE              Reviewed;         110 AA.
AC   Q25504;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Larval cuticle protein 16/17;
DE   Flags: Precursor;
GN   Name=LCP16/17;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Abdominal epidermis;
RX   PubMed=2924995; DOI=10.1016/0012-1606(89)90226-1;
RA   Horodyski F.M., Riddiford L.M.;
RT   "Expression and hormonal control of a new larval cuticular multigene family
RT   at the onset of metamorphosis of the tobacco hornworm.";
RL   Dev. Biol. 132:292-303(1989).
CC   -!- FUNCTION: Component of the cuticle of the larva of tobacco hornworm.
CC       Seems to participate in the formation of 5- to 10-fold thinner lamellae
CC       in the endocuticle.
CC   -!- TISSUE SPECIFICITY: Specific to the epidermis. Expressed in all the
CC       epidermal cells of day 3 larvae except for the bristle cells and those
CC       at the muscle attachment sites.
CC   -!- DEVELOPMENTAL STAGE: Expressed late on the penultimate day of feeding
CC       in the fifth larval instar. Highest levels throughout the final day of
CC       feeding. Barely detectable by the day of wandering. Expression stops
CC       when the metamorphosis begins.
CC   -!- INDUCTION: In day 1 epidermis, by exposure to hydroxyecdysone in vitro
CC       without juvenile hormone.
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DR   EMBL; M25486; AAA50287.1; -; Genomic_DNA.
DR   PIR; A37370; A37370.
DR   PIR; B37370; B37370.
DR   AlphaFoldDB; Q25504; -.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   2: Evidence at transcript level;
KW   Cuticle; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..110
FT                   /note="Larval cuticle protein 16/17"
FT                   /id="PRO_0000006409"
FT   DOMAIN          34..107
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   VARIANT         64
FT                   /note="K -> D"
SQ   SEQUENCE   110 AA;  12240 MW;  998BCFBD3318F691 CRC64;
     MKLIILVALT LAAVVANEPE PPKILRSEYD QKPEGSYVFG FETEDGISRD ETGEVKEALD
     EDNKPHSVVV VRGQYSYVDP DGNPQVIKYY ADETGYHAEG DSIPKVPSRR