ID   CU18A_LOCMI             Reviewed;         185 AA.
AC   P83994;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2004, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Cuticle protein 18.6, isoform A;
DE   AltName: Full=LM-ACP 18.6A;
DE            Short=LM-18.6A;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Pharate adult cuticle {ECO:0000269|PubMed:12573245};
RX   PubMed=12573245; DOI=10.1016/s1570-9639(02)00531-9;
RA   Kalume D.E., Kieffer S., Rafn K., Skou L., Andersen S.O., Roepstorff P.;
RT   "Sequence determination of three cuticular proteins and isoforms from the
RT   migratory locust, Locusta migratoria, using a combination of Edman
RT   degradation and mass spectrometric techniques.";
RL   Biochim. Biophys. Acta 1645:152-163(2003).
CC   -!- FUNCTION: Component of the cuticle of migratory locust which contains
CC       more than 100 different structural proteins.
CC       {ECO:0000269|PubMed:12573245}.
CC   -!- DOMAIN: The tetrapeptide (A-A-P-[AV]) repeats found throughout the
CC       protein are also present in many proteins constituting the protective
CC       envelope of other species. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=18557.4; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12573245};
CC   -!- MASS SPECTROMETRY: Mass=18549.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12573245};
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DR   AlphaFoldDB; P83994; -.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   1: Evidence at protein level;
KW   Cuticle; Direct protein sequencing; Repeat.
FT   CHAIN           1..185
FT                   /note="Cuticle protein 18.6, isoform A"
FT                   /id="PRO_0000196098"
FT   REPEAT          21..24
FT                   /note="1"
FT                   /evidence="ECO:0000305"
FT   REPEAT          33..36
FT                   /note="2"
FT                   /evidence="ECO:0000305"
FT   REPEAT          41..44
FT                   /note="3"
FT                   /evidence="ECO:0000305"
FT   REPEAT          54..57
FT                   /note="4"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          64..134
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   REPEAT          133..136
FT                   /note="5"
FT                   /evidence="ECO:0000305"
FT   REPEAT          139..142
FT                   /note="6"
FT                   /evidence="ECO:0000305"
FT   REPEAT          150..153
FT                   /note="7"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   185 AA;  18556 MW;  F77019A4D2767BD6 CRC64;
     GYLGAPAVVA PGAPLAARAY AAPAYAAPLA RYAAPVARAY AAPVARAYAP AVAAAPAAVE
     YDPHPQYSFA YNVQDAHTGD SKTQHESRDG DVVQGSYSLA EPDGSIRVVD YTADPVNGFN
     AVVHKEAGAH PAAAPVAVAA PVAHAPVAVA APVRAYAAPL ARAAYAAPIA RASYGPALAY
     GGAYH