CU22_TENMO
ID CU22_TENMO Reviewed; 199 AA.
AC P26968; Q27015;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Adult-specific cuticular protein ACP-22;
DE Flags: Precursor;
GN Name=ACP22;
OS Tenebrio molitor (Yellow mealworm beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrio.
OX NCBI_TaxID=7067;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1728581; DOI=10.1016/0012-1606(92)90268-l;
RA Bouhin H., Charles J.-P., Quennedey B., Delachambre J.;
RT "Developmental profiles of epidermal mRNAs during the pupal-adult molt of
RT Tenebrio molitor and isolation of a cDNA clone encoding an adult cuticular
RT protein: effects of a juvenile hormone analogue.";
RL Dev. Biol. 149:112-122(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9087546; DOI=10.1111/j.1365-2583.1993.tb00128.x;
RA Bouhin H., Braquart C., Charles J.-P., Quennedey B., Delachambre J.;
RT "Nucleotide sequence of an adult-specific cuticular protein gene from the
RT beetle Tenebrio molitor: effects of 20-hydroxyecdysone on mRNA
RT accumulation.";
RL Insect Mol. Biol. 2:81-88(1993).
CC -!- FUNCTION: Cuticular proteins play a significant role in determining the
CC physical properties of cuticles.
CC -!- TISSUE SPECIFICITY: Epidermal regions synthesizing hard cuticle.
CC -!- DEVELOPMENTAL STAGE: Preecdysial adult cuticle deposition.
CC -!- INDUCTION: By 20-hydroxyecdysone.
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DR EMBL; X60455; CAA42985.1; -; mRNA.
DR EMBL; X72783; CAA51290.1; -; Genomic_DNA.
DR PIR; S16063; S16063.
DR PIR; S32224; S32224.
DR AlphaFoldDB; P26968; -.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 2: Evidence at transcript level;
KW Cuticle; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..199
FT /note="Adult-specific cuticular protein ACP-22"
FT /id="PRO_0000006415"
FT DOMAIN 133..199
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT REGION 63..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 138
FT /note="S -> Y (in Ref. 2; CAA51290)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 20710 MW; 1EBF2D1DBEC6739F CRC64;
MRLFIILSVA SFGAIGVLSQ GGGGGGAAGG LLEGGGGFEE YGHRSRGSII GLSRGIEIGR
HYGGGGGGGG EGEEGREHEL RGGGLELGGG GGGGGGGGGG GGEGRHYEIG FGGSHFNTPV
DVHHEEAIHL KAHPEYHSDY HVADHKTKDF KSKHEVRDGY KVKGTYSLLE PDHKTVRVVD
YVSDKKRGFI ARVSYRKHH