ID   CU3A_CONNA              Reviewed;          16 AA.
AC   P0DMB3;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Conotoxin nt3a {ECO:0000303|PubMed:22776330};
OS   Conus natalis (Natal textile cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Leptoconus.
OX   NCBI_TaxID=257336;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=22776330; DOI=10.1016/j.peptides.2012.07.002;
RA   Peigneur S., Van Der Haegen A., Moller C., Waelkens E., Diego-Garcia E.,
RA   Mari F., Naude R., Tytgat J.;
RT   "Unraveling the peptidome of the South African cone snails Conus pictus and
RT   Conus natalis.";
RL   Peptides 41:8-16(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22776330}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22776330}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       3 branch, since 3 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1742.7; Method=Electrospray; Note=monoisotopic
CC       mass.; Evidence={ECO:0000269|PubMed:22776330};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DMB3; -.
DR   ConoServer; 5859; Nt3a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..16
FT                   /note="Conotoxin nt3a"
FT                   /evidence="ECO:0000269|PubMed:22776330"
FT                   /id="PRO_0000425158"
FT   DISULFID        2..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        3..15
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..16
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   16 AA;  1750 MW;  53AC7D733DC67862 CRC64;
     GCCRFPCPDS CRSLCC