CU51C_CONCL
ID CU51C_CONCL Reviewed; 76 AA.
AC D2Y169;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Conotoxin Cal5a L3 {ECO:0000303|PubMed:21172372};
DE Contains:
DE RecName: Full=Conotoxin Cal5b L3 {ECO:0000303|PubMed:21172372};
DE Contains:
DE RecName: Full=Conotoxin Cal5.1 {ECO:0000303|PubMed:21172372};
DE Flags: Precursor;
OS Californiconus californicus (California cone) (Conus californicus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX NCBI_TaxID=1736779;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA Gilly W.F.;
RT "Diversity of conotoxin types from Conus californicus reflects a diversity
RT of prey types and a novel evolutionary history.";
RL Toxicon 57:311-322(2011).
CC -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC channels. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:21172372}.
CC -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC 'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC and AC P81755). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR EMBL; GU290199; ADB43126.1; -; mRNA.
DR AlphaFoldDB; D2Y169; -.
DR ConoServer; 3981; Cal5.1 L2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Disulfide bond; Hydroxylation; Ion channel impairing toxin; Neurotoxin;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..42
FT /evidence="ECO:0000305|PubMed:21172372"
FT /id="PRO_5000566283"
FT PEPTIDE 44..74
FT /note="Conotoxin Cal5a L3"
FT /evidence="ECO:0000305|PubMed:21172372"
FT /id="PRO_0000414964"
FT PEPTIDE 54..74
FT /note="Conotoxin Cal5b L3"
FT /evidence="ECO:0000305|PubMed:21172372"
FT /id="PRO_0000414965"
FT PEPTIDE 61..74
FT /note="Conotoxin Cal5.1"
FT /evidence="ECO:0000305|PubMed:21172372"
FT /id="PRO_5000566284"
FT MOD_RES 50
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 58
FT /note="4-hydroxyproline; partial"
FT /evidence="ECO:0000250"
FT MOD_RES 62
FT /note="4-hydroxyproline; partial"
FT /evidence="ECO:0000250"
FT MOD_RES 64
FT /note="4-hydroxyproline; partial"
FT /evidence="ECO:0000250"
SQ SEQUENCE 76 AA; 8344 MW; 96BA3A10ED67EAEC CRC64;
MRFYIGLMAA LMLTSVLRTD SASVGQTGTK SELAVIERVI RQRDAADVKP VARQNEGPGR
DPAPCCQHPI ETCCRR