ID   CU65_CONTE              Reviewed;          23 AA.
AC   P0DPM3;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Conotoxin Tx6.5 {ECO:0000305};
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, AND HYDROXYLATION AT PRO-12.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22709442}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22709442}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC       {ECO:0000250|UniProtKB:Q26443}.
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DR   AlphaFoldDB; P0DPM3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Knottin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..23
FT                   /note="Conotoxin Tx6.5"
FT                   /evidence="ECO:0000269|PubMed:22709442"
FT                   /id="PRO_0000445063"
FT   MOD_RES         12
FT                   /note="4-hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:22709442"
FT   DISULFID        2..10
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        5..15
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        9..20
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
SQ   SEQUENCE   23 AA;  2495 MW;  1A99BDBB7DC8AD4B CRC64;
     NCPYCVVYCC PPAYCQASGC RPP