ID   CU68_CONAA              Reviewed;          68 AA.
AC   A0A346CED7;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2018, sequence version 1.
DT   03-AUG-2022, entry version 7.
DE   RecName: Full=Conotoxin Am6.8 {ECO:0000305};
DE   AltName: Full=Conotoxin Am2473 {ECO:0000303|PubMed:29947227};
DE   Flags: Precursor;
OS   Conus amadis (Amadis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Leptoconus.
OX   NCBI_TaxID=198732;
RN   [1] {ECO:0000312|EMBL:AXL93751.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 46-68, PYROGLUTAMATE
RP   FORMATION AT GLN-46, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=29947227; DOI=10.1021/acs.jproteome.8b00132;
RA   Vijayasarathy M., Basheer S.M., Balaram P.;
RT   "Cone Snail Glutaminyl Cyclase Sequences from Transcriptomic Analysis and
RT   Mass Spectrometric Characterization of Two Pyroglutamyl Conotoxins.";
RL   J. Proteome Res. 17:2695-2703(2018).
CC   -!- FUNCTION: Probable toxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29947227}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:29947227}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin U superfamily. {ECO:0000305}.
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DR   EMBL; MG917726; AXL93751.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..45
FT                   /evidence="ECO:0000305|PubMed:29947227"
FT                   /id="PRO_0000454998"
FT   PEPTIDE         46..68
FT                   /note="Conotoxin Am6.8"
FT                   /evidence="ECO:0000269|PubMed:29947227"
FT                   /id="PRO_5016641381"
FT   MOD_RES         46
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:29947227"
FT   DISULFID        47..55
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        50..60
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        54..65
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
SQ   SEQUENCE   68 AA;  7740 MW;  F12612FB86E57DCF CRC64;
     MIRMGFFLTL TVAVLLTSLT CSEAVPTDKR EMERLFDRIL LKDQRQCPYC VVHCCPPSYC
     QASGCRPP