ID   CU6B_CONLG              Reviewed;          27 AA.
AC   P0DOZ1;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Conotoxin Lo6/7b {ECO:0000303|PubMed:27801785};
OS   Conasprella longurionis (Cone snail) (Conus longurionis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conasprella; Fusiconus.
OX   NCBI_TaxID=1077918;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT TYR-27, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, AND SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=27801785; DOI=10.3390/md14110199;
RA   Lebbe E.K., Ghequire M.G., Peigneur S., Mille B.G., Devi P.,
RA   Ravichandran S., Waelkens E., D'Souza L., De Mot R., Tytgat J.;
RT   "Novel conopeptides of largely unexplored indo Pacific Conus sp.";
RL   Mar. Drugs 14:199-216(2016).
CC   -!- FUNCTION: 1 uM of this toxin does not show any effect on voltage-gated
CC       sodium and potassium channels. Does not show antibacterial activity on
CC       both Gram-negative and Gram-positive bacteria (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27801785}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:27801785}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P0CH19}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- MASS SPECTROMETRY: Mass=2775.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27801785};
CC   -!- MISCELLANEOUS: Does not show effect on Nav1.1, Nav1.2, Nav1.3, Nav1.4,
CC       Nav1.5, Nav1.6, Nav1.7 (PubMed:27801785). Does not show effect on
CC       Kv1.1, Kv1.3, Kv1.4, Kv1.5, Kv1.6 and Kv3.1 (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785}.
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DR   AlphaFoldDB; P0DOZ1; -.
DR   SMR; P0DOZ1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Knottin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..27
FT                   /note="Conotoxin Lo6/7b"
FT                   /evidence="ECO:0000269|PubMed:27801785"
FT                   /id="PRO_0000439363"
FT   MOD_RES         27
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:27801785"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..19
FT                   /evidence="ECO:0000250"
FT   DISULFID        15..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   27 AA;  2782 MW;  9909D7A867F00770 CRC64;
     SCLSSGALCG IDSNCCNGCN VPRNQCY