ID   CU73_CONVC              Reviewed;          68 AA.
AC   W4VSE7;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=Conotoxin Vc7.3 {ECO:0000303|PubMed:24505301};
DE   Flags: Precursor;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1] {ECO:0000312|EMBL:JAB84617.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24505301; DOI=10.1371/journal.pone.0087648;
RA   Robinson S.D., Safavi-Hemami H., McIntosh L.D., Purcell A.W., Norton R.S.,
RA   Papenfuss A.T.;
RT   "Diversity of conotoxin gene superfamilies in the venomous snail, Conus
RT   victoriae.";
RL   PLoS ONE 9:E87648-E87648(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24505301}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:24505301}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin U superfamily. {ECO:0000305}.
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DR   EMBL; GAIH01000100; JAB84617.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..45
FT                   /evidence="ECO:0000305|PubMed:24505301"
FT                   /id="PRO_0000454996"
FT   PEPTIDE         46..68
FT                   /note="Conotoxin Vc7.3"
FT                   /evidence="ECO:0000305|PubMed:24505301"
FT                   /id="PRO_5004852201"
FT   DISULFID        47..55
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        50..60
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        54..65
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
SQ   SEQUENCE   68 AA;  7648 MW;  83058F58B6F8C9EA CRC64;
     MIRMGFFLTL TVAVLLTSLI CTEAVPTDKR GMERLFDQVL LKDQRNCPYC VVYCCPPAYC
     QASGCRPP