ID   CU82_CONCL              Reviewed;         131 AA.
AC   D3JYA6;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Conotoxin Cal8.2 {ECO:0000305};
DE   AltName: Full=Conotoxin CalMKLL-2 {ECO:0000303|PubMed:21172372};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The cysteine framework is C-C-C-C-C-C-C-C-C.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
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DR   EMBL; GU332644; ADC35042.1; -; mRNA.
DR   AlphaFoldDB; D3JYA6; -.
DR   ConoServer; 4056; Cal8.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..38
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_0000414996"
FT   PEPTIDE         39..131
FT                   /note="Conotoxin Cal8.2"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000570823"
SQ   SEQUENCE   131 AA;  14807 MW;  B8DDD22F0936A2DF CRC64;
     MKLLLTLLLG SALMCITLAD ECGLGTHRPV KEVIDNVRTM YYCDCRAGDA ERSITVSRCD
     DNNQKQDDVI LTYCGLEQTT GCNTNPYTAA KHDSSGDKPQ FYCSCLNYKY EQSHADSRYW
     TIRCYMGDIC D