ID   CUA1_DROME              Reviewed;         135 AA.
AC   Q26416; Q9VLY2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Adult cuticle protein 1;
DE   AltName: Full=dACP-1;
DE   Flags: Precursor;
GN   Name=Acp1; ORFNames=CG7216;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=Canton-S; TISSUE=Head;
RX   PubMed=7875368; DOI=10.1006/dbio.1995.1038;
RA   Qiu J., Hardin P.E.;
RT   "Temporal and spatial expression of an adult cuticle protein gene from
RT   Drosophila suggests that its protein product may impart some specialized
RT   cuticle function.";
RL   Dev. Biol. 167:416-425(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Component of the cuticle of the adult fruit fly. Could be
CC       involved in thickening of the hard adult cuticle.
CC       {ECO:0000269|PubMed:7875368}.
CC   -!- TISSUE SPECIFICITY: Detected in the epidermis underlying the head and
CC       thorax (including legs and wings), but not in the abdominal epidermis
CC       of newly eclosed flies. {ECO:0000269|PubMed:7875368}.
CC   -!- DEVELOPMENTAL STAGE: Expression starts around 72 hours after
CC       pupariation, peaks 12 hours after eclosion and decreases thereafter to
CC       undetectable levels by 3 days after eclosion.
CC       {ECO:0000269|PubMed:7875368}.
CC   -!- DOMAIN: The tetrapeptide (A-A-P-[AV]) repeats found throughout the
CC       protein are also present in many proteins constituting the protective
CC       envelope of other species.
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DR   EMBL; S76894; AAB33567.2; -; Genomic_DNA.
DR   EMBL; AE014134; AAF52547.1; -; Genomic_DNA.
DR   EMBL; AY119158; AAM51018.1; -; mRNA.
DR   RefSeq; NP_477115.1; NM_057767.4.
DR   AlphaFoldDB; Q26416; -.
DR   BioGRID; 60191; 13.
DR   STRING; 7227.FBpp0079123; -.
DR   PaxDb; Q26416; -.
DR   PRIDE; Q26416; -.
DR   DNASU; 34052; -.
DR   EnsemblMetazoa; FBtr0079500; FBpp0079123; FBgn0014454.
DR   GeneID; 34052; -.
DR   KEGG; dme:Dmel_CG7216; -.
DR   CTD; 52; -.
DR   FlyBase; FBgn0014454; Acp1.
DR   VEuPathDB; VectorBase:FBgn0014454; -.
DR   eggNOG; ENOG502T9P8; Eukaryota.
DR   GeneTree; ENSGT00940000176369; -.
DR   HOGENOM; CLU_148241_0_0_1; -.
DR   InParanoid; Q26416; -.
DR   OMA; TVGAWPP; -.
DR   OrthoDB; 1626044at2759; -.
DR   PhylomeDB; Q26416; -.
DR   BioGRID-ORCS; 34052; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Acp1; fly.
DR   GenomeRNAi; 34052; -.
DR   PRO; PR:Q26416; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0014454; Expressed in insect adult head and 9 other tissues.
DR   ExpressionAtlas; Q26416; baseline and differential.
DR   Genevisible; Q26416; DM.
DR   GO; GO:0008012; F:structural constituent of adult chitin-based cuticle; IC:FlyBase.
DR   GO; GO:0008365; P:adult chitin-based cuticle development; IEP:FlyBase.
DR   InterPro; IPR031874; Cuticle_Acp1.
DR   PANTHER; PTHR12336; PTHR12336; 1.
DR   Pfam; PF15955; Cuticle_4; 1.
PE   2: Evidence at transcript level;
KW   Cuticle; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..135
FT                   /note="Adult cuticle protein 1"
FT                   /id="PRO_0000006402"
FT   REPEAT          72..75
FT                   /note="1"
FT   REPEAT          78..81
FT                   /note="2"
FT   REPEAT          128..131
FT                   /note="3"
SQ   SEQUENCE   135 AA;  13119 MW;  76A322083ADC362D CRC64;
     MKFAVAVIFT LALAMGVQSS VIPLLSQVAG HGLSYTAVSG PAVVASPWAV PAAHWPAAVN
     VASWPPAAIH AAAPAVLAAP APAVVAAHAP SVVVAPVAHS GVYTAQTRGA IHTAPLAGHI
     QSVASINAAP APGTL