ID   CUB2_PLARH              Reviewed;         132 AA.
AC   A0A6B9KZ30;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   17-JUN-2020, sequence version 1.
DT   03-AUG-2022, entry version 5.
DE   RecName: Full=Venom CUB domain-containing protein 2 {ECO:0000303|PubMed:31752210};
DE   Flags: Precursor;
OS   Platymeris rhadamanthus (Red spot assassin bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Platymeris.
OX   NCBI_TaxID=1134088;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=31752210; DOI=10.3390/toxins11110673;
RA   Walker A.A., Robinson S.D., Undheim E.A.B., Jin J., Han X., Fry B.G.,
RA   Vetter I., King G.F.;
RT   "Missiles of mass disruption: composition and glandular origin of venom
RT   used as a projectile defensive weapon by the assassin bug Platymeris
RT   rhadamanthus.";
RL   Toxins 11:E673-E673(2019).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31752210}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland (posterior main gland)
CC       (at protein level). {ECO:0000269|PubMed:31752210}.
CC   -!- SIMILARITY: Belongs to the venom CUB family. {ECO:0000305}.
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DR   EMBL; MN208307; QHB21496.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.120.290; -; 1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 1.
DR   SMART; SM00042; CUB; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..132
FT                   /note="Venom CUB domain-containing protein 2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5025379123"
FT   DOMAIN          22..129
FT                   /note="CUB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        66..125
FT                   /evidence="ECO:0000305"
FT   DISULFID        77..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
SQ   SEQUENCE   132 AA;  14392 MW;  3FB3331DC01732F0 CRC64;
     MKTLFLAIAL FSAVALAEEK SESAELVPGG EAFVVESVNY PEDASANLKQ TWKLTTTAGN
     FIHLECTDIR LFEDKPCGDW ALTFDDGGNV TEMCTTSFDH KFTSKTNTLT LTLRTGRDAR
     GFVACKATAT KK