CUBN_CAEEL
ID CUBN_CAEEL Reviewed; 4047 AA.
AC Q20911; Q23242;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 4.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Cubilin homolog {ECO:0000312|WormBase:ZC116.3};
DE Flags: Precursor;
GN Name=cubn-1 {ECO:0000312|WormBase:ZC116.3};
GN ORFNames=ZC116.3 {ECO:0000312|WormBase:ZC116.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2005, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-806; ASN-811; ASN-1762;
RP ASN-2005; ASN-2645; ASN-3421; ASN-3787 AND ASN-3858, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- FUNCTION: Cotransporter which plays a role in lipoprotein, vitamin and
CC iron metabolism, by facilitating their uptake. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; BX284605; CAA98557.3; -; Genomic_DNA.
DR EMBL; Z74473; CAA98557.3; JOINED; Genomic_DNA.
DR PIR; T22812; T22812.
DR RefSeq; NP_506157.3; NM_073756.5.
DR SMR; Q20911; -.
DR BioGRID; 44749; 1.
DR STRING; 6239.ZC116.3; -.
DR iPTMnet; Q20911; -.
DR EPD; Q20911; -.
DR PaxDb; Q20911; -.
DR PeptideAtlas; Q20911; -.
DR PRIDE; Q20911; -.
DR EnsemblMetazoa; ZC116.3.1; ZC116.3.1; WBGene00013855.
DR GeneID; 179729; -.
DR KEGG; cel:CELE_ZC116.3; -.
DR UCSC; ZC116.3; c. elegans.
DR CTD; 179729; -.
DR WormBase; ZC116.3; CE42882; WBGene00013855; cubn-1.
DR eggNOG; KOG4292; Eukaryota.
DR HOGENOM; CLU_000172_1_0_1; -.
DR InParanoid; Q20911; -.
DR OMA; RGFTVRW; -.
DR OrthoDB; 4105at2759; -.
DR PhylomeDB; Q20911; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR PRO; PR:Q20911; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013855; Expressed in embryo and 2 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 17.
DR Gene3D; 2.60.120.290; -; 24.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR Pfam; PF00431; CUB; 15.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 3.
DR SMART; SM00042; CUB; 23.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF49854; SSF49854; 23.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 20.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 3.
PE 1: Evidence at protein level;
KW Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Lipid metabolism;
KW Protein transport; Reference proteome; Repeat; Secreted; Signal; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..4047
FT /note="Cubilin homolog"
FT /id="PRO_0000248516"
FT DOMAIN 168..205
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 207..248
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 306..345
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 346..387
FT /note="EGF-like 4; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 388..435
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 438..475
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 476..512
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 518..641
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 645..763
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 769..934
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 934..1061
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1065..1182
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1188..1300
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1304..1427
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1428..1558
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1560..1680
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1691..1841
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1955..2083
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2207..2334
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2335..2463
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2467..2588
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2590..2717
FT /note="CUB 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2721..2859
FT /note="CUB 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2996..3121
FT /note="CUB 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3127..3254
FT /note="CUB 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3255..3385
FT /note="CUB 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3387..3508
FT /note="CUB 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3515..3641
FT /note="CUB 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3645..3783
FT /note="CUB 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3786..3900
FT /note="CUB 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT REGION 2052..2071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 537
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 583
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 775
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 806
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 811
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 942
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1513
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1613
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1631
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1648
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1674
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1762
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 1782
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1866
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1890
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2005
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 2016
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2017
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2305
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2434
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2599
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2645
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 2657
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2692
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2811
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2845
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2875
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2988
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3421
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3461
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3635
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3770
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3787
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3812
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3858
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3930
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 172..183
FT /evidence="ECO:0000250"
FT DISULFID 177..193
FT /evidence="ECO:0000250"
FT DISULFID 195..204
FT /evidence="ECO:0000250"
FT DISULFID 211..227
FT /evidence="ECO:0000250"
FT DISULFID 221..236
FT /evidence="ECO:0000250"
FT DISULFID 238..247
FT /evidence="ECO:0000250"
FT DISULFID 310..321
FT /evidence="ECO:0000250"
FT DISULFID 315..330
FT /evidence="ECO:0000250"
FT DISULFID 333..344
FT /evidence="ECO:0000250"
FT DISULFID 350..363
FT /evidence="ECO:0000250"
FT DISULFID 357..372
FT /evidence="ECO:0000250"
FT DISULFID 375..386
FT /evidence="ECO:0000250"
FT DISULFID 392..403
FT /evidence="ECO:0000250"
FT DISULFID 397..418
FT /evidence="ECO:0000250"
FT DISULFID 420..434
FT /evidence="ECO:0000250"
FT DISULFID 442..453
FT /evidence="ECO:0000250"
FT DISULFID 447..463
FT /evidence="ECO:0000250"
FT DISULFID 465..474
FT /evidence="ECO:0000250"
FT DISULFID 480..491
FT /evidence="ECO:0000250"
FT DISULFID 485..500
FT /evidence="ECO:0000250"
FT DISULFID 502..511
FT /evidence="ECO:0000250"
FT DISULFID 518..544
FT /evidence="ECO:0000250"
FT DISULFID 577..601
FT /evidence="ECO:0000250"
FT DISULFID 645..667
FT /evidence="ECO:0000250"
FT DISULFID 696..719
FT /evidence="ECO:0000250"
FT DISULFID 769..801
FT /evidence="ECO:0000250"
FT DISULFID 877..896
FT /evidence="ECO:0000250"
FT DISULFID 1065..1091
FT /evidence="ECO:0000250"
FT DISULFID 1120..1145
FT /evidence="ECO:0000250"
FT DISULFID 1188..1211
FT /evidence="ECO:0000250"
FT DISULFID 1234..1262
FT /evidence="ECO:0000250"
FT DISULFID 1304..1330
FT /evidence="ECO:0000250"
FT DISULFID 1428..1455
FT /evidence="ECO:0000250"
FT DISULFID 1488..1522
FT /evidence="ECO:0000250"
FT DISULFID 1560..1586
FT /evidence="ECO:0000250"
FT DISULFID 1614..1641
FT /evidence="ECO:0000250"
FT DISULFID 1691..1720
FT /evidence="ECO:0000250"
FT DISULFID 1955..1979
FT /evidence="ECO:0000250"
FT DISULFID 2006..2027
FT /evidence="ECO:0000250"
FT DISULFID 2207..2238
FT /evidence="ECO:0000250"
FT DISULFID 2265..2295
FT /evidence="ECO:0000250"
FT DISULFID 2335..2368
FT /evidence="ECO:0000250"
FT DISULFID 2395..2424
FT /evidence="ECO:0000250"
FT DISULFID 2467..2498
FT /evidence="ECO:0000250"
FT DISULFID 2590..2619
FT /evidence="ECO:0000250"
FT DISULFID 2646..2668
FT /evidence="ECO:0000250"
FT DISULFID 2721..2747
FT /evidence="ECO:0000250"
FT DISULFID 2786..2809
FT /evidence="ECO:0000250"
FT DISULFID 2996..3025
FT /evidence="ECO:0000250"
FT DISULFID 3052..3074
FT /evidence="ECO:0000250"
FT DISULFID 3127..3154
FT /evidence="ECO:0000250"
FT DISULFID 3181..3217
FT /evidence="ECO:0000250"
FT DISULFID 3255..3281
FT /evidence="ECO:0000250"
FT DISULFID 3315..3335
FT /evidence="ECO:0000250"
FT DISULFID 3387..3418
FT /evidence="ECO:0000250"
FT DISULFID 3445..3468
FT /evidence="ECO:0000250"
FT DISULFID 3515..3544
FT /evidence="ECO:0000250"
FT DISULFID 3645..3680
FT /evidence="ECO:0000250"
FT DISULFID 3708..3742
FT /evidence="ECO:0000250"
FT DISULFID 3786..3815
FT /evidence="ECO:0000250"
FT DISULFID 3845..3863
FT /evidence="ECO:0000250"
SQ SEQUENCE 4047 AA; 453276 MW; F8A620A00A68F649 CRC64;
MIPNLQLFLS LILFGLLNHV SSIDYEEIHI EDSYETRSRI LMVDGNVWLH AGKDKNITFK
TTGNGRIYVD ETDVSKLPDI ASFKQLVGRI ENTSQMFTTL KSRQDTQTSA MRVVLNSAKH
YLVALRNMTL EVNILKKWKT DKMARDMRRR GLLVKMTRQI IGINKLIAIN ACDPNKCSNG
GTCIPSFGAK FTCLCPPHFT GTTCEADIDE CSVYNGTTAG CQNNGTCINN RGGFECQCQS
GYHGSLCQYH MSACSKTFEL CGPHGHCIES IVDPTGQSSS DTTTYKCICD WGFKVSSDKN
NPTCVDVNEC ESNPCHPGVD CINLPGSFVC SGCPKGYKTD GNVCIDVNEC EGEIRVCSPL
SKCHNTLGSY YCDSCPTGYS GDGGNCVKDD SCVKNKCHKL ATCKVTDDGY SAVGDYTCYC
PDGYVGDGIG EEGCVKSASN VCQNHNCVNA GKCKPTSDTE YKCECEAGFL GKFCEKTSPC
QTNPCKNGGT CIAVENSAYC DCPEHFFGRA CEEEEEHCGS HFTHSSGNYT FDLQRSNKTE
LSICDFVFNI PAANSAVVMT FTEFDKFTQE GSGPTDCAKT DANLTLYDGP EDSSSEFATF
CGDSHSVHAP LSDTPITMTS TGAMLRFRGT QGSFTIKWET VERKCGYRSS KPEGIISVPQ
NHQDIVCEWF ISAPGGKIIE VTIPPVSMHS KDIEKCDQNS LEIYDGYATY DKHRILETCS
STLESQVVRT TGPFLTVAFI SNMLQSDAGL ETIRGFVLKY KFTTPDRECG AEIDNDSNDF
SFSGVIESPN YGSLYPPNMD CTWKINGTLS NGSYSGDMVL KLTFDEYDVK SGFSANGPGM
HYRSFRRLLP RNEVEYGIAP GFSRVFAYRN LFDMGTCTND FLKIHDGDGT LVQETCNPRR
PPNVLTVNNP AAVLTFHSDS AEQGKGFRIQ YEMLCEKRVN GNGTIQTWNF PNGGAAGTCT
YIIEAPKTHV ISVRFLTIGL RVLPMSECFY TPNAVETYEN YVEFSGGRTD NALFNRRYVC
ARYPFVEGAW MSVSAARRLQ IKVGSDGNPM FKGLSLEYKT SDVGCGGVFS SMTGTISSPN
YPEKYQPHMH CVYNLYVSWS KTVKLTFDVF DLEVTPAKSC EYDRVEIYTS YHNETVHGEL
LGKFCGAMIP PSIYSTTNTM AVVFVSDRSV AGPGWNAKFE AVSRKTTCDF TLTAPSNNLI
FDPQQLKFDK CTYHIAVHEN QRILIKMNNM SLPCDKSSLM FRNGPSETSP PFSSLPPESE
ICTPKVNYMP VIRSFSNRVT IVYKSINSEG SFFNLTYETI TSGCGGRVDG LTGIVSAPQY
PLGDKKNLKC DWTVAVALGN KVRFALTALD DLNSSDSGGF CPLFAANRID FFDSALQGNQ
HLKRYCAKEM ASEPITSDDN ELIIKYVQSG GFQSKKIFGF SGHFTTLCNG IVHEAISGSI
QSPGYPYKVY SNQFCTWTIK VPKGNRIVAT VHHFSISQKS YFEGGINCIT DMLKVDDTDL
AEAEVTFKKT DYNITNSVNK YCDKAIPRVI RSRHNSMKLT YSSQGDPTNQ FWLSWNTLGC
SRDITAPQQL IITKENIDPE VDEFECQYKI QAPIGKQINL KIDKMDILPI GTNCTYTKDF
SGFAIFMSDS NKSGTPFQTY CSSINQQNIS SHTNELFLFL SMKKDKLKTN VFFNATVEFV
DVPQSSQSDI CGQVINLERG KKNYITSPGY PSAYLPGIKC NFLINAPPGY HIEYALEKYY
SPYYHDDRKT DKPRFMSPYT ANYTCKWYLA YNVGMLSFYE GNSSSSSPVE RLCDESDTVQ
TFELYASQSL VIFEGASNYM SQKSGEGVRD QIGFVLSMIP KCGGVVYAES KPQTISLYHE
GEGICNVTIK KKDPQDSEIN IRLEEYTKLN SSSTHTIDDR IDIYVGGVLK YTEMLKATDN
TMQEYASDEE MMISVQNANA PHSAIIVVST DDKSCGGEVR HSQGTIYAPT RRLDKPFDCG
WAISNSNGNT VTLSILDHNL KSTPNCTDSY IEIRANNSSG KLIKRQCDIS SIDSTEYESQ
SLYVFLRYRP SASDGNDDDD DTPDIDQQDS NKRPLFKARY EKVSGGRPKS RYVSSPMIDN
TEMMVWTLDI VDEKAGILVK FIDLYLPSPT SYLRFTESGE NDDVASSDYE EVTGVMAPAE
KFFETNLIRV YGKLEKSDKF SFTWDPVPLN YRNLTLAKDK PAKVYDCGGD LTPTYEWDYF
TNPLPAGQSF GYEENLHCRW IIRRPMFTGI ELKFDYLELE DVQNCAFDFV SFRLQFDDQP
EENDDVDLSS VSKHCALVRS NNTFNFSVNR ALHIHFVTDR SRHGIGFKLK YRLTCNSFEH
IRPGIFFEHT LTSPNYDGNF HTPSVWKCQY SLIIESNRKV SVEIVDLDIQ ENSPCSYNNA
LILGNRFSEL VETHSQYSKS SKYCGKLEQG ERLNFTSARG RLFIKYNSGP NSRKGFKMII
KEQLTECPSG VLHVDDNSPS RVLNSPEFPQ RIPNSVECEY VMAAPNGHRL MLTFDSENFD
IDGNQKNCDL LDYIEIRDGP TVHSEVIGIY CGNQAPSTIF STTNFLYMKL HTSEYGKSRR
FVATYGIATC GGTVMVRENV TTHITSPSFP YPFATPVQCQ WNVKSPNTHM IEAKVDHVWL
FYNPNCTMEQ LMIRDGNSTA NPLIGPVCVP RHAPDVFTRS ASNQITVQFT SNSTTTRGGR
QYCSNKKCGF DVAVTMSGEK CGGRITNLIG TLTPPGYPGK LLSHVKCIWD FKMKPGFIYR
FKITFPGANA YHKFDNQVFR IAKQHCFPDV AVVEGFPPYD GAQYSTYFCK NETQITSITD
TIRIVYDDSH TREMISAIGN DQPLNSTFYA PFTIDYMAIP ANSENQGCTL QINKNLTTEF
HLRNKVNGKG VGLDSFCHVS IEKPANFESV HIEISDYKAD SELQPAGAKC FSWGAHLKIK
SDEPVPIETT VCDGKSMKNK QSEMIYVNPQ IDLFISQLFR DQEGQQFNLT IEFQKCGGVI
SSPNTGDITS PNFGSGLKYL PGSKCRWVLE APEGQIVKVK IVEMQIAYDH ECENDHLIIG
EGRQADVNTI HKYCHKMDGE QEQKLEDRFK IIKSHGRYLT LIWVTNMKYE EAGWKIQYEF
LNENEECGYH TSGMSGTIYT PMFGDKDYEN DLECVWDIQV PLGYHINLKF KDFDVETAEN
CAKDQLLISQ EHSTRANSPN GDYYFLFQDE EKETPLCGIE HPKDFESESN RVRLNFTTDS
QTTARGFRVN WEAECGAIYR LNHGVITSPY YPNGYPNDIT CTYLIAPPDQ NSVIAIKFAD
FDLATMRTSF GRAPCEDDYL QIIDTGTDRV LHTFCASEPM PKDALVFKGA IGLKFVSDKS
YYWMEEDNKY GRKGSKGFQL AYSINKCGDN IELREGTGFI TTVTSPAFPL PYTKDLDCVW
NITTDPNRQL NIRFEEMKLE AFHDCSADYI EFFDSSDIMA NKTLGKFCGT MDKIPQYRIV
TSGPNLLIHM RTDFNVNSGG FKLAVISSLG QKEGCGGKLT ATTSWQTLTS PKDEDGNYPP
ALLCGWTISG PVDSQLQIRI DGVDTEQLEY PPGDRPSPEC IDALAIYDGQ EFFSPLLAGD
ICTSGTPLPK ILYTSHRHAF ITFETDRDGT GRGFNISYSI VDSDCGGWLK ATNEIKTLVY
KGITSDDNKE MNKERSHQRC RFMIQGPKTE PVIVNFQQFN IPSKAGDCSD SFVEIRDVGS
LQECKHPACA REPNQRKITK LCGTHVPTSH VSNTNTIQII VSADIMPNKN QSRPSLKFEY
NILDSCNRTI DTNTIKSGRL TSPNYPQVYS ENSTCVTNLQ SSNQKMLLVF NDFTLEEPNN
VNKNCDYDYL MLKEGDSNGT YYCGSTLPKA LMTSGKDLTA LLKSDHSLNH AGYDASYYTV
VSERDDQIQF ADSYELEGVI SSIGYPNGYN KSYTQIFTLR PPNSHDCSII FTDVSISMTQ
LPEECFQPTE EYLEIEVKFK TQVKKARIRS CTFALKKARE LILEADNNDR YIKFAFKSDA
KSENDGRGFK IRWKCHSIGK TQAVLPS
