ID   CUBT_TRIIF              Reviewed;         133 AA.
AC   Q45KX2;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=Triatox {ECO:0000312|EMBL:AAZ38957.1};
DE   AltName: Full=Venom CUB domain-containing protein 1 {ECO:0000250|UniProtKB:A0A6B9L3R4};
DE   Flags: Precursor;
OS   Triatoma infestans (Assassin bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Triatoma.
OX   NCBI_TaxID=30076;
RN   [1] {ECO:0000312|EMBL:AAZ38957.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Feijo G.C.S., Teixeira A.R.L.C.;
RT   "A toxin of Triatoma infestans salivary glands.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:ABR27914.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND POSSIBLE FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=18207082; DOI=10.1016/j.ibmb.2007.11.001;
RA   Assumpcao T.C.F., Francischetti I.M.B., Andersen J.F., Schwarz A.,
RA   Santana J.M., Ribeiro J.M.C.;
RT   "An insight into the sialome of the blood-sucking bug Triatoma infestans, a
RT   vector of Chagas' disease.";
RL   Insect Biochem. Mol. Biol. 38:213-232(2008).
CC   -!- FUNCTION: May function as an antimicrobial peptide and may be related
CC       to the innate defense of the insect in the salivary glands.
CC       {ECO:0000305|PubMed:18207082}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18207082}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:18207082}.
CC   -!- MISCELLANEOUS: Predicted to be an amphipathic alpha-helix.
CC       {ECO:0000305|PubMed:18207082}.
CC   -!- SIMILARITY: Belongs to the venom CUB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ38957.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=ABR27914.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DQ126071; AAZ38957.1; ALT_INIT; mRNA.
DR   EMBL; EF639029; ABR27914.1; ALT_INIT; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antimicrobial; Disulfide bond; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..133
FT                   /note="Triatox"
FT                   /id="PRO_5010138385"
FT   DOMAIN          23..125
FT                   /note="CUB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        70..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
SQ   SEQUENCE   133 AA;  14473 MW;  FADCE962C2E5A676 CRC64;
     MTTLRVLLAV CCAAYCILAE DVTVPANGEL KLMPDQKAGG RLEGQWKIST PDHYYLIVSC
     GLWSSASGTC KDKILITQGG KTTEVCGEGK NSFYVQQDTN LNTAEIIILT NTPDARAMCT
     VYSAEKPKEE NTF