ID   CUC2C_HAECO             Reviewed;         210 AA.
AC   P16252;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Cuticle collagen 2C;
DE   Flags: Fragment;
GN   Name=2C;
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Haemonchidae; Haemonchus.
OX   NCBI_TaxID=6289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2615789; DOI=10.1016/0166-6851(89)90104-7;
RA   Shamansky L.M., Pratt D., Boisvenue R.J., Cox G.N.;
RT   "Cuticle collagen genes of Haemonchus contortus and Caenorhabditis elegans
RT   are highly conserved.";
RL   Mol. Biochem. Parasitol. 37:73-86(1989).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment.
CC   -!- MISCELLANEOUS: This protein shows 4 potential triple-helical regions,
CC       which contain glycine as every third amino acid.
CC   -!- MISCELLANEOUS: In all nematode cuticle collagens, the polypeptide
CC       chains are complexed within the cuticle by disulfide bonds and other
CC       types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR   EMBL; J04670; AAA29172.1; -; mRNA.
DR   PIR; B44984; B44984.
DR   AlphaFoldDB; P16252; -.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   InterPro; IPR008160; Collagen.
DR   Pfam; PF01391; Collagen; 2.
PE   2: Evidence at transcript level;
KW   Collagen; Cuticle; Repeat.
FT   CHAIN           <1..210
FT                   /note="Cuticle collagen 2C"
FT                   /id="PRO_0000127606"
FT   REGION          11..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..106
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..150
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   210 AA;  19562 MW;  E15FAA9A2DF3D74B CRC64;
     QAGYGNCQAC CTGGQAGPPG MPGNPGRPGN PGAPGIPGNP GRPPVQPCDP IPIPPCKPCP
     QGRPGPPGPI GPPGEPGTPG NPGAPGNDAP PGPPGPKGPP GPPGKAGAPG AAGQPGANAP
     SEPLVPGPPG PPGPTGPEGP PGPNGAPGHP GAPGAPGEKG PRGQDGHPGA PGNAGHPGQP
     GQPGPPGERG VCPKYCSMDG GVFFEDGTRR