ID   CUE2A_XENLA             Reviewed;         273 AA.
AC   Q6NU18; Q8JJ43;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=CUE domain-containing protein 2-A;
DE   AltName: Full=Mitotic phosphoprotein 38;
GN   Name=cuedc2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PHOSPHORYLATION.
RX   PubMed=11818060; DOI=10.1016/s0960-9822(01)00662-5;
RA   Georgi A.B., Stukenberg P.T., Kirschner M.W.;
RT   "Timing of events in mitosis.";
RL   Curr. Biol. 12:105-114(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in targeting proteins for ubiquitination and
CC       subsequent proteasomal degradation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:11818060}.
CC   -!- SIMILARITY: Belongs to the CUEDC2 family. {ECO:0000305}.
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DR   EMBL; AF419151; AAM33246.1; -; mRNA.
DR   EMBL; BC068784; AAH68784.1; -; mRNA.
DR   RefSeq; NP_001082244.1; NM_001088775.1.
DR   AlphaFoldDB; Q6NU18; -.
DR   SMR; Q6NU18; -.
DR   DNASU; 398317; -.
DR   GeneID; 398317; -.
DR   KEGG; xla:398317; -.
DR   CTD; 398317; -.
DR   Xenbase; XB-GENE-6251606; cuedc2.S.
DR   OrthoDB; 1410219at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 398317; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd14367; CUE_CUED2; 1.
DR   InterPro; IPR039805; CUE_CUED2.
DR   InterPro; IPR039784; CUEDC2.
DR   PANTHER; PTHR12493; PTHR12493; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..273
FT                   /note="CUE domain-containing protein 2-A"
FT                   /id="PRO_0000282996"
FT   DOMAIN          135..178
FT                   /note="CUE"
FT   REGION          92..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        160
FT                   /note="S -> F (in Ref. 1; AAM33246)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  30585 MW;  E7C8567DCA13AE2F CRC64;
     MALEKIIRES LTGFIQCHIP HADLSALDEV FYAYATGVLE ELGSQNSSEE DFEMESFVEM
     LEAYIPGFSE ISSGKVYDML FELSRRLSEA RGKENVSPKP TAEVSFMTPT SSSTESSKKI
     ETEPLEGAVA QEKDDAKNGI DLLLEIFPSC TVSQAQTALS MAKGDLEDAV QIIVDGKVIA
     DNHSGSKDLQ GAPKTDDLKD FILQKYMLVD TEDDKKTYRP VAPKEAPKKM IRYIDNQVVS
     TKGERYKDIK KPESEEMKKT YINLKPARKY KFH