CUE4_SCHPO
ID CUE4_SCHPO Reviewed; 215 AA.
AC P87238;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=CUE domain-containing protein 4, mitochondrial;
DE Flags: Precursor;
GN ORFNames=SPCC4G3.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAB09768.1; -; Genomic_DNA.
DR PIR; T41363; T41363.
DR RefSeq; NP_587825.1; NM_001022818.2.
DR PDB; 6OP8; X-ray; 1.70 A; B=152-215.
DR PDBsum; 6OP8; -.
DR AlphaFoldDB; P87238; -.
DR SMR; P87238; -.
DR BioGRID; 276103; 4.
DR STRING; 4896.SPCC4G3.13c.1; -.
DR iPTMnet; P87238; -.
DR MaxQB; P87238; -.
DR PaxDb; P87238; -.
DR PRIDE; P87238; -.
DR EnsemblFungi; SPCC4G3.13c.1; SPCC4G3.13c.1:pep; SPCC4G3.13c.
DR GeneID; 2539541; -.
DR KEGG; spo:SPCC4G3.13c; -.
DR PomBase; SPCC4G3.13c; -.
DR VEuPathDB; FungiDB:SPCC4G3.13c; -.
DR eggNOG; ENOG502S6YF; Eukaryota.
DR HOGENOM; CLU_1475953_0_0_1; -.
DR InParanoid; P87238; -.
DR OMA; RWFFNRD; -.
DR PRO; PR:P87238; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000836; C:Hrd1p ubiquitin ligase complex; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IDA:PomBase.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISO:PomBase.
DR InterPro; IPR003892; CUE.
DR Pfam; PF02845; CUE; 1.
DR SMART; SM00546; CUE; 1.
DR PROSITE; PS51140; CUE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Transit peptide;
KW Ubl conjugation pathway.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 30..215
FT /note="CUE domain-containing protein 4, mitochondrial"
FT /id="PRO_0000310344"
FT DOMAIN 48..90
FT /note="CUE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT REGION 109..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 181..212
FT /evidence="ECO:0007829|PDB:6OP8"
SQ SEQUENCE 215 AA; 23524 MW; 397A2F1DF8F3B629 CRC64;
MQPEQLAGCA VVLTVTVLTL RWMFRVDKGG EVSESRTSSS GVDNEPPVNS EHVHLVKTVF
PHLESSAIAY DLQKTKNVDA TIENALRGQP LPLPPRNSSL YARFPLSAGA GASSHSEETT
PSHEVTSNVS SGSSASSLAS NEHRSLIETY NLSSRISSSD NSSSSTGNEE VRNRSKLPSS
KKEREELFRK RKEEMILAAR KRMEGKIKGE KQDKN
