CUE6_CONCL
ID CUE6_CONCL Reviewed; 61 AA.
AC D2Y168; D6C4J5;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Conotoxin Cal14.6 {ECO:0000305};
DE AltName: Full=Conotoxin Cal14.2 {ECO:0000303|PubMed:21172372};
DE AltName: Full=Conotoxin Cal14a {ECO:0000303|PubMed:21172372};
DE AltName: Full=Conotoxin Cl14.6 {ECO:0000303|PubMed:20363338};
DE AltName: Full=Conotoxin Cl14a {ECO:0000303|PubMed:20363338};
DE Flags: Precursor;
OS Californiconus californicus (California cone) (Conus californicus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX NCBI_TaxID=1736779;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 40-61, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA Olivera B.M.;
RT "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT 1844.";
RL Mol. Phylogenet. Evol. 56:1-12(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], HYDROXYLATION AT PRO-57, AMIDATION AT PRO-60,
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom, and Venom duct;
RX PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA Gilly W.F.;
RT "Diversity of conotoxin types from Conus californicus reflects a diversity
RT of prey types and a novel evolutionary history.";
RL Toxicon 57:311-322(2011).
CC -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC channels. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20363338,
CC ECO:0000269|PubMed:21172372}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:20363338, ECO:0000305|PubMed:21172372}.
CC -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC -!- PTM: Contains 2 disulfide bonds.
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DR EMBL; FJ959137; ADB93107.1; -; Genomic_DNA.
DR EMBL; GU290198; ADB43125.1; -; mRNA.
DR AlphaFoldDB; D2Y168; -.
DR ConoServer; 3980; Cal14.6 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..38
FT /evidence="ECO:0000305|PubMed:20363338,
FT ECO:0000305|PubMed:21172372"
FT /id="PRO_5000566281"
FT PEPTIDE 40..60
FT /note="Conotoxin Cal14.6"
FT /evidence="ECO:0000269|PubMed:21172372,
FT ECO:0000305|PubMed:20363338"
FT /id="PRO_5000566282"
FT MOD_RES 57
FT /note="4-hydroxyproline; partial"
FT /evidence="ECO:0000305|PubMed:21172372"
FT MOD_RES 60
FT /note="Proline amide"
FT /evidence="ECO:0000305|PubMed:21172372"
FT CONFLICT 28
FT /note="G -> R (in Ref. 1; ADB93107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 61 AA; 6448 MW; B3CF9BF7DA396289 CRC64;
MKFLLFLSVA LLLTSFIETE AGPVNEAGVE RLFRALVGRG CPADCPNTCD SSNKCSPGFP
G
